EAS Formal Lab (1)

Emily synthesized acetanilide by stirring aniline and acetic anhydride together in water at 100C. Acetanilide is a solid at room temperature, while everything else is a liquid. Emily noted that while the reaction was running, everything was dissolved and the liquid was a pale orange. Emily allowed the reaction to cool to room temperature and then cooled it in an ice bath. After the slow cooling, a solid appeared. 1. Based only on Emily's observations from this procedure, what solvent does she know will work to recrystallize the acetanilide if needed? aniline aqueous ethanol water acetic acid 2. According to PubChem, acetanilide melts at 114°C. Emily measured a melting point of 96 - 104°C for the solid they collected. What can be said about this solid? - Melting point does not indicate whether a sample is pure or not - The experimental range is narrow and close to the literature value, suggesting it is not completely pure - The experimental range is narrow…

A student attempted to prepare 1-chlorobutane by mixing 1-butanol with NaCl in acetone. Was the student succesful? Explain.

You are employed as a coop student at the Drug and Alcohol Testing Association of Canada (DATAC) developing analytical tests for sports doping agents. You are asked to prepare a procedure for the extraction of methylphenidate, the active compound in Ritalin, from urine samples (consider them as simple aqueous layers, you do not need to consider other components!). The goal of the procedure is to extract the methylphenidate into an organic layer which will then be evaporated, and the residue will be tested for the drug.Your colleague is helping you develop the urine test. They suggest that the urine should be adjusted to a pH above 7 before extracting with the organic solvent. Why is this necessary? Support your explanation with a full arrow-pushing mechanism for the reaction that would occur if the pH was below 7. Include all formal charges, intermediates (if applicable) and products.

You are employed as a coop student at the Drug and Alcohol Testing Association of Canada (DATAC) developing analytical tests for sports doping agents. You are asked to prepare a procedure for the extraction of methylphenidate, the active compound in Ritalin, from urine samples (consider them as simple aqueous layers, you do not need to consider other components!). The goal of the procedure is to extract the methylphenidate into an organic layer which will then be evaporated, and the residue will be tested for the drug.You find that methylphenidate is highly soluble in 2-methyltetrahydrofuran, a bio-renewable solvent. Draw the structure of 2-methyltetrahydrofuran and give two reasons why it is a good solvent choice for liquid-liquid extraction.

what would the overall reaction be for the recrystillzation of aspirin using 91% isopropanol to get pure aspirin?(drawn out) what would the mechanism be(if any)?   More information provided below:   You are removing salt, talc and other impurities to get pure aspirin. Recrystallization is a useful technique that can be used to purify solid organic compounds. Thistechnique involves the solubility of organic solids in various solvents. For recrystallization towork properly, the target compound must dissolve in a solvent when it is hot and not dissolvewhen it is cold. In this experiment you will isolate pure aspirin from aspirin tablets. Aspirin tabletscontain various salts and impurities in addition to aspirin. By using recrystallization, you will beable to remove the impurities and be left with pure aspirin.Sometimes pairs of solvents can used to produce better results. In this experiment, 91%isopropanol will be used to recrystallize aspirin. The 91% isopropanol contains 91%…

pluginfile.php/477064/modresource/content/0/Chem%20154%20Exam%202%20F2019%20Loudon%20ch%204.pdf ch 4.pdf 3/5 5.1 Mechanisms. Using curved arrows, suggest a reasonable mechanism for each indicated reaction. H3PO4 water, dilute a) b) H3PO4 HO. H20

To determine the purity of a synthetic preparation of methylethyl ketone, C4H8O, it was reacted with hydroxylamine hydrochloride, liberating HCl (reaction: NH2OH.HCl + C4H8O -> C4H9NO + H20 + HCl). In a typical analysis a 3.00-mL sample was diluted to 50.00 mL and treated with an excess of hydroxylamine hydrochloride. The liberated HCl was titrated with 1.2149 M NaOH, requiring 35 mL to reach the end point. A. Write the acid base reaction involved in the titration. B. Report the percent purity of the sample given that the density of methylethyl ketone is 0.805 g/mL.

What factors during the experiment caused the percent yield to be different than 100%? What impurities may be present in the final product (look at the spectroscopic data for evidence of this), and how does that effect the percent yield calculation? I got 64% for the percent yield.

Suppose you took your two compounds, dissolved them in tertbutyl methyl ether and then added them to a separatory funnel.  Now suppose you add in aqueous sodium bicarbonate and vigorusly shake the contents of the separatory funnel. ethanol will be dissolved in tert butyl methyl ether ether and valeric acid will be dissolved in the aqueous sodium bicarbonate layer. Draw the EXACT chemical structure that will exist in each of the layers after shaking with sodium bicarbonate.  (Is it neutral or charged?)

1. To pass Chem 18.1, ELIBAP must be able to determine the melting points of three ester compounds extracted and purified from three different plants. Ester 1 Ester 2 Ester 3 :0: H. MW: 182.17 g/mol MW: 152.15 g/mol MW: 164.20 g/mol Possible Melting Points: -31 °C 64-67 °C -9 °C a. Given the molar mass and molecular structures of the esters, determine their most possible melting points. b. According to her friend who took Chem 18.1 last semester, one of the ester compounds exists as a solid above room temperature (25 °C) while the rest remain in their liquid forms. Identify the ester which is present in solid form above room temperature. Draw the structure.

The purpose of this experiment is to use both extraction and crystallization techniques to separate a solid mixture of organic compounds. You will receive a packet with 1 g of a unknown (pH is basic) amide solid sample which will contain three components, one from each group: Group 1 (~50% wt):  ethyl 4-aminobenzoate, ortho-toluic acid, or benzoic acid  Group 2 (~40% wt):  fluorene, 1,4-dibromobenzene, benzil, benzoin Group 3 (~10% wt):  fluorene, 1,4-dibromobenzene, benzil, benzoin (but not the same as Group 2 compound) Create a lab procedure that will allow you to successfully isolate, purify, and identify the two major (Group 1 and Group 2) components of the unknown amide sample.  reagents that can be used are 1M HCl, 6M HCl, 1M NaOH, 6M NaOH, diethyl ether, and methylene chloride

A mixture of the two compounds shown below is dissolved in ether. Using the information given in the experiment, select all the correct statements regarding the extraction and isolation of the two compounds. محمد age X Y A. X can be extracted from the organic layer using hydrochloric acid. OB. Y can precipitate if hydrochloric acid is added to the salt of Y in the aqueous layer. OC. Y can be extracted from the organic layer using hydrochloric acid. D. X can precipitate if hydrochloric acid is added to the salt of X in the aqueous layer

OH 0140769 filler EXPERIMENT 11 RADICAL COUPLING REACTION (Preparation of 1, 1-bis-2-naphthol) FeCl3 - Drop of H₂O - Grinding - rt OH 1.13909 1, 11199 1.13579 Chemicals Required: 2.88069 2.8843 2-Naphthol - 2.88 g Iron(III) chloride - 1.10 g Water - 2 drops -sumins 2.88 242 Toluene (for recrystallization) 640 41725 P Procedure: 2.8 0.1082 Grind a mixture of 2-naphthol (2.88 g) and iron(III) chloride (1.10 g) with 2 drops of water in an agate (or porcelain) mortar pestle for about 20 minutes. Allow the mixture to stand for 1 hr 10 mins with a little grinding now and then. Transfer the mixture with water (40 ml) into a 100 ml beaker and boiled for 10-15 minutes. Cool the mixture and filter the product, wash with boiling water (10 ml), dry and recrystallize from toluene. Report the yield and melting point of the product. Remember to hand in your product. Data Treatment and Analysis 1. Calculate the % yield for the product and show your working. Determine the % error if possible. 2.…

b. When added to an immiscible mixture of dichloromethane and water, which layer would you expect the following compounds to primarily be found in? Explain. i. limonene CH3 CH3 CHM 2070 Lab Fall 2020 ii. acetic acid HOCH3 i. benzaldehyde

Aldehydes can be determined indirectly by atomic absorption. The aldehyde is oxidized with the Ag+ ion producing 2 moles of Ag for every mole of the aldehyde. Silver dissolves and is determined by atomic absorption. When examining a liquor, 50 mL were subjected to the treatment, the metallic silver was separated and dissolved, making the resulting solution 20 mL for its reading. A 10 ppm Ag solution was examined under the same conditions; The readings obtained were: 0.423 and 0.242 for the standard and the sample respectively. Assuming full adherence to Beer's Law, calculate the mg of acetaldehyde in 100 mL of liquor.

10. Fractional Distillation: This lab was viewed via a video and described in detail in lab class. You are distilling apart hexane (bp = 68) and toluene (bp 110). Your boiling point for the first fraction is 48°C. Why is the boiling point so low (most likely reason)? !! azeotrope with water non-resonance of hexane O resonance of toluene student error O seriously impaired thermometer

Imagine that phenol (“hydroxybenzene”) and nitrobenzene are reacted (in separate beakers) with a hot solution containing both concentrated sulfuric acid and concentrated nitric acid. A) In analyzing the products, you discover that the substitution pattern resulting from the reaction with phenol differs from the reaction with nitrobenzene. Explain this difference in substitution patterns using one or more judiciously selected reaction mechanisms or portions of mechanisms.

Please answer the question at the bottom, Thanks. LAB NOTES FOR PREPARATION OF BUTYL MAGNESIUM BROMIDEAND ITS SUBSEQUENT CONVERSION TO AN ALCOHOL To the reaction flask were added 2.5967 gram of magnesium turnings, about 20 mlof diglyme, and a solution of 13.5942 gram of butyl bromide in about 25 mldiglyme.The procedure as per the lab manual was initiated. After the required heating timewas completed the reaction mixture was allowed to cool to room temperature.Then a solution of 6.1123 gram of acetone in about 15 ml of diglyme was addeddropwise as per the lab manual.The rest of the lab manual procedure was completed, ultimately affording 2.5532gram of an oily, clear and slightly yellow liquid, presumed to be 2-methyl-2-hexanol. Boiling point as measured by distillation was 138 – 141 deg C.About 0.8 ml of the presumed 2-methyl-2-hexanol was placed in an NMR tube towhich was added 2 drops of TMS. The tube was capped, then inverted and righted20 times to thoroughly mix the product and…

Please answer the question at the bottom, Thanks. LAB NOTES FOR PREPARATION OF BUTYL MAGNESIUM BROMIDEAND ITS SUBSEQUENT CONVERSION TO AN ALCOHOL To the reaction flask were added 2.5967 gram of magnesium turnings, about 20 mlof diglyme, and a solution of 13.5942 gram of butyl bromide in about 25 mldiglyme.The procedure as per the lab manual was initiated. After the required heating timewas completed the reaction mixture was allowed to cool to room temperature.Then a solution of 6.1123 gram of acetone in about 15 ml of diglyme was addeddropwise as per the lab manual.The rest of the lab manual procedure was completed, ultimately affording 2.5532gram of an oily, clear and slightly yellow liquid, presumed to be 2-methyl-2-hexanol. Boiling point as measured by distillation was 138 – 141 deg C.About 0.8 ml of the presumed 2-methyl-2-hexanol was placed in an NMR tube towhich was added 2 drops of TMS. The tube was capped, then inverted and righted20 times to thoroughly mix the product and…

Three sample, X (neutral), Y (basic), and Z (acidic), were mixed and dissolved together in dichloromethane. Propose a method to separate all given sample individually using the combination of liquid-liquid extraction, crystallization, distillation, and sublimation technique.

Answer the following questions following a Solubility and recrystalization lab for organic chemisty.  1. In a solubility and recrystallization lab you are working with the following chemicals : solids (benzoic acid, acetanilide,naphthalene, and resorcinol) and three solvents (water, ethanol and petroleumether) discuss and rank the polarity of the solvents and the polarity of the compounds being investigated. 2. Briefly describe how a mixture of sand and benzoic acid (soluble in hotwater) could be separated to produce pure benzoic acid.

Pcdotte Use a flow chart to show how you could separate a mixture of the following compounds using an extraction. Be sure to include all steps to get pure materials. НО.

Do both plz dont give incomplete solution DO BOTH MUST

Importance of melting point in Dehydration Reaction Of 2-Methylcyclohexanol And Phosphoric Acid. Does it help us predict anything?

In the synthesis of Sudan-1, the following precursors were used: Aniline – 0.2 mL β-naphthol – 0.35 g   Experimental data Weight of vial, g 13.1085 Weight of vial + recrystallized product, g 13.4714 Experimental melting point, °C 129-132 Given this data: What is the theoretical yield? What is the percent yield? What is the purity of the dye based on experimental melting point (theoretical is 131-133 °C) Please show solutions and equations

Calculate theoretical yield of the Grignard reaction synthesis of triphenylmethanol from bromobenzene. Amounts of products used are listed in the image.

In the workup of the grignard reaction of turning bromobenzene to benzoic acid, we start by mixing the grignard with HCl and diethyl ether. We discard the aqueous layer and wash the organic layer with water. Then, the organic layer is extracted with NaOH. Then, the extracts are heated to remove ether. Then, it is precipitated with HCl. Precipitate collected. Let it dry and finally, purified with toluene and hexanes. Please make a flowchart of the process of this workup indicating what products and byproducts are forming. And what compounds are in the aqueous layer and organic layer in the steps.

Choose the correct steps in the dehydration of secondary alcohol; then, arrange inchronological order.I - Formation of AlkeneII - Formation of AldehydeIII - Formation of Protonated alcoholIV - Undergoes E2 mechanismV-Undergoes E1 mechanismA. V-III-IB. IV-III-IIC. III-V-ID.III-IV-II  Ethanol is heated with an acidified potassium manganate (VII) solution. What would be theproduct of this reaction?A. EthanalB. EtheneC. Ethanoic acidD. Ethane ALL of the following Ether can be prepared by Williamson's method, EXCEPT:A. Ditertbutyl etherB. Ethyl-tert-butyl etherC. anisoleD. Both A & B. Which of the following is not true of SN1 reactions?A. They are favored by nonpolar solvents.B. The concentration of nucleophiles does not affect the rate of reaction.C. Tertiary alkyl halides generally react through this mechanism.D. They occur through a 2-step concerted reaction. Butan-1-ol is formed from which of the following reactant-reaction pairs?A. Butanal - reduction reactionB. Butanone -…

which among the organic liquids best match compound e based on its reaction to the various reagents? ethanol acetic acid benzaldehyde acetone ethyl acetate

If 80% of a desired compound is extracted into the organic phase in each step (leaving 20% in the aqueous layer), how many extractions are necessary to ensure that at least 99% of the compound has been recovered in the organic phase?      1 extraction     2 extractions     3 extractions     4 extractions

Please give a reasonable mechanism for the following reaction using a multiple component reactions. Please draw it out and write out the steps. PLEASE SHOW WITH ARROWS. 5 PhNH + n-Bu 10 mol% TI (NM)2(doma) + ABU-NC tol 100 °C, 48 h, 77% Bu n-Bu

The nitration of the 2-amine toluene is able to occurs with only nitric acid. Interestingly it occurs to the meta position in relation to the amino group. Amines are stronger activators compared to the methyl groups. Explain in your own words a feasible reason to explain why the reaction takes place at this position and not ortho/para in relation to the amine. CH HN. HN. 65% HNO, Ethanol NO MeSO,H Imatinib einhainnente nale PatnteUI