Module 7 Worksheet

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Keck Graduate Institute *

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4

Subject

Chemistry

Date

Jan 9, 2024

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docx

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7

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Answer the following multiple-choice questions. There is no time limit, and you may save and return to your work as many times as you need to before submitting the worksheet. But you may submit this worksheet only once. Flag question: Question 1 Question 1 1 pts If drug X has a half-life ( T 1/2 ) of 2 days (48 hours) and the concentration at 12:00 today was 10 µg/mL, what would the expected concentration of drug X be at 12:00 tomorrow? Group of answer choices 7 µg/mL 5 µg/mL 2.5 µg/mL 8 µg/mL Flag question: Question 2 Question 2 1 pts If a drug is administered orally, which of the following would affect the efficiency of its absorption in the gastrointestinal tract? Group of answer choices Dissociation of the drug from its administered form All of these answers are correct. Diffusion of the drug across gastrointestinal membranes The drug's solubility in gastrointestinal fluid Flag question: Question 3 Question 3 1 pts If a trough specimen is required for therapeutic drug monitoring, the most appropriate time to collect the specimen would be: Group of answer choices Immediately before the next dose is given Eight hours after the last dose was given Immediately after the dose is administered Three days after the dose was administered
Flag question: Question 4 Question 4 1 pts Which of the following statements concerning procainamide is TRUE? Group of answer choices Procainamide is metabolized into an active metabolite with similar antiarrhythmic activity. Procainamide should be administered intravenously due to poor absorption. Procainamide is an antibiotic used to treat gram-positive bacterial infections. Procainamide is eliminated entirely through renal filtration. Flag question: Question 5 Question 5 1 pts Which of the following statements concerning lithium is TRUE? Group of answer choices Lithium is completely metabolized in the liver with no renal elimination. Lithium is used to treat depression, self-mutilating behavior, and bipolar disorder. Lithium is used in conjunction with cyclosporine to prevent transplant rejection. Lithium toxicity has been associated with ototoxicity and nephrotoxicity. Flag question: Question 6 Question 6 1 pts Which of the following is the primary purpose for measuring serum concentrations of methotrexate? Group of answer choices To ensure that serum concentrations are within the therapeutic range To determine the amount of leucovorin needed to halt methotrexate action To confirm serum concentrations when toxicity is suspected To determine the optimum dosage for oral administration of methotrexate Flag question: Question 7 Question 7 1 pts Primidone is converted by the liver into which of the following antiepileptic drugs? Group of answer choices Gabapentin Phenobarbital Ethosuximide Clozapine
Flag question: Question 8 Question 8 1 pts Bilirubin competes with some drugs for the same binding site on plasma proteins. What effect would an increased concentration of bilirubin in the blood (bilirubinemia) have on the potential activity of this drug? Group of answer choices The fraction of bound drug would increase thereby decreasing potential activity. The fraction of bound drug would increase thereby increasing potential activity. The fraction of bound drug would decrease thereby increasing potential activity. The fraction of bound drug would decrease thereby decreasing potential activity. Flag question: Question 9 Question 9 1 pts Twenty milligrams (mg) of drug Y is injected intravenously. One hour after the injection, blood is collected and assayed for the concentration of drug Y. If the concentration of drug Y in this specimen was 0.4 mg/L, what is the volume of distribution for this drug? Group of answer choices 8 L 50 L 20 L 0.8 L Flag question: Question 10 Question 10 1 pts A new orally administered drug has been introduced in your institution. It is unclear whether TDM is needed for this drug. What factors should be taken into consideration when addressing this question? Group of answer choices All of these factors should be taken into consideration. Consequences of a subtherapeutic concentration. Predictability of serum concentrations after a standard oral dose. Proximity of the toxic range to the therapeutic range.
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