Extraction Post Lab (2)

Multistep synthesis of Lidocaine Lab 1) How many grams of starting material do you need? It is given in moles below but how many grams? 2) How to calculate theoretical yield? Part One Method A. Preparation of alpha-Chloro-2,6-dimethylacetanilideCombine 0.033 mol of 2,6-dimethylaniline with 25 mL of glacial acetic acid (or ethyl acetateor THF) and 0.033 mol of alpha-chloroacetyl chloride, in that order, in an appropriately sized Erlenmeyer flask. With the aid of a hot water bath, warm the solution to 40-50°C, remove the flask from the bath, and add a solution of 5 g of sodium acetate trihydrate dissolved in 100 mL of water.

Benzyl alcohol and methyl benzoate (shown below) are dissolved in an ether solution. Choose the best process to separate the following two compounds using an acid-base extraction. 28 benzyl alcohol methyl benzoate A) Add aqueous NaOH and extract the benzyl alcohol into the aqueous layer. B) Add aqueous NaHCO3 and extract the benzyl alcohol into the aqueous layer. C) Add aqueous NaOH and extract the methyl benzoate into the aqueous layer. 3 D) Add aqueous HCI and extract the benzyl alcohol into the aqueous layer. E) These two compounds cannot be separated using an acid-base extraction.

Name this compound:

A fellow student somehow mixed an aspirin sample with paracetamol after synthesising both. Explain how you would separate aspirin from paracetamol using liquid-liquid extraction.

Illustrate the Separation of cyclohexanamine and cyclohexanol by an extraction procedure ?

draw the following reactions and label it properly 1. Esterification of benzoic acid with n-propyl alcohol and  concentrated H2SO4. 2. Esterification of salicylic acid with n-propyl alcohol and  concentrated H2SO4. 3. Esterification of acetic acid with n-propyl alcohol and  concentrated H2SO4. 4.Reaction with neutral FeCl3 with acetic acid 5. Reaction with neutral FeCl3 with tartaric acid

Answer the following.

22. The following reaction to synthesize phenacetin was conducted using 2 mmol of acetaminophen and 30 mmol of ethyl iodide. Which of the following statements is true? 2 mmol OH 30 mmol NaOH MeOH 55 °C a. 30 equivalents of ethyl iodide were used b. the theoretical yield of phenacetin in mmol is 2 mmol c. the theoretical yield of phenacetin in mmol is 30 mmol d. the theoretical yield of phenacetin in mmol is 32 mmol

20. Which of the following statements is false?       Positive result for an aldehyde is indicated by an orange to red precipitate using Tollen’s reagent.       Both the 2nd & 3rd statements only.       Positive result for an aldehyde is indicated by a greenish precipitate using 2,4-DNPH reagent.       Positive result for a ketone is indicated by a red-orange precipitate using chromic acid test.       All of the above

Why do we react β-naphthol with ethyl iodide rather than react ethyl alcohol with 2-Iodo naphthalene? Draw out a putative mechanism for ethyl alcohol reactingwith 2- Iodo naphthalene and explain why this method wouldn’t work. in Synthesis of Nerolin experemint

When doing an acid-base extraction, why would one use sodium hydroxide rather than sodium bicarbonate to deprotonate acetylsalicyclic acid to make a salt?

3

ANSWER ALL AND WILL GIVE YOU THUMBS UP AND RATE YOU GOOD Classify the following examples to the given agents. CHOICES: Suspending agent Emulsifying agent   QUESTIONS: Bentonite Kaolin   Lecithin Carbomer Polysorbate 20 Carrageenan Methyl cellulose Ceteareth 20 Tragacanth Mustard

Question attached

1. What is the merchanism of synthesis of salicylamide? 2. Does the boiling temperature too high affect the performance synthesis of salicylamide? 3. Comparison of likelihood of an amide reaction between salicylic acids, methyl salicylate and ethyl salicylate?

You have learned that ester may be hydrolyzed in aqueous base. Why does a workup using 50ml of 10% NaOH and 50g of ice not hydrolyze a nitro benzocaine derivative?

The catalog prices for all reagents used to make Phenacetin are shown: p-ethoyxanaline: 100 grams, $26.00 (Weight used: 2.5 grams) Acetic Anhydride: 1000 grams, $39.50 (Weight used: 2.2 grams, Density: 1.08) Hydrochloric Acid: 2500 mL, $30.20 (Weight used: 1.53 grams, Density: 1.02) Sodium Acetate Trihydrate: 500 grams, $30.50 (Weight used: 3.0 grams) Calculate the cost of each reagent.

How does methyl 2-acetoxybenzoate or Aspirin methyl ester hydrolise.  Please show detailes.

Answer the following.

Nabumetone is a pain reliever and anti-inflammatory agent sold under the brand name of Relafen.a. Write out a synthesis of nabumetone from ethyl acetoacetate.b. What ketone and alkyl halide are needed to synthesize nabumetone by direct enolate alkylation?

Based on these results which is more acidic carboxylic acids or phenols? Explain why.

Benzoic acid and water were added to the test tube labeled "b.a." After stirring the mixture, sodium hydroxide (NaOH) vas added until the solid disappeared. Finally, hydrochloric acid was added drop by drop until blue litmus paper turned red. The solid present in the test tube after the addition of HCI is most likely: benzoic acid benzyl acetate O benzyl chloride sodium benzoate

Suppose you took your two compounds, dissolved them in tertbutyl methyl ether and then added them to a separatory funnel.  Now suppose you add in aqueous sodium bicarbonate and vigorusly shake the contents of the separatory funnel. ethanol will be dissolved in tert butyl methyl ether ether and valeric acid will be dissolved in the aqueous sodium bicarbonate layer. Draw the EXACT chemical structure that will exist in each of the layers after shaking with sodium bicarbonate.  (Is it neutral or charged?)

Account for the greater amount of internal pressure in the aspirin extraction versus the ß- naphthol extraction.Why does the sequence for extracting the diethyl ether solution of aspirin acid, naphthalene, and ß-naphthol start with aqueous bicarbonate and follow with aqueous hydroxide rather than the reverse order?