Extraction Post Lab (2)

Explain the purpose of the Qualitative Tests for carbonyls and Unknown carbonyl.

A mixture of compounds is dissolved in ether, and extracted with 10% NaHCO3 solution. The aqueous extract is treated with 6M HCI solution, and extracted with dichloromethane. If the mixture contains an amine, where is it? The bottom layer of the first extraction O The top layer of the second extraction The top layer of the first extraction The bottom layer of the second extraction

Consider the following possible compounds Compound Benzophenone Naphthalene Cinnamic acid Aspirin 3-Chlorobenzoic acid Sulfanilamide MP (°C) 48-49 79-80 133 136 154 165-166 1. A solid melts is found to melt at the range 153-161 °C. What could it be? a. Pure aspirin b. Pure 3-chlorobenzoic acid c. Pure sulfanilamide d. Impure aspirin e. Impure 3-chlorobenzoic acid f. Impure sulfanilamide

5. The pKas of chemicals HX and HY are 5.0 and 7.0 respectively. The pKa of carbonic acid H,CO, 3. is 6.0. If you made up an ether solution of chemicals HX and HY in a separatory funnel, and then added an aqueous solution of sodium bicarbonate NaHCO3 to that separatory funnel, would both HX and HY stay in the ether layer? Or would either or both of them transfer into the aqueous layer? If one goes into the water layer, will it be in its neutral HX/HY form, or in it's deprotonated anionic form? ilter HX: ether layer or water layer? If in the water layer, in HX or X- form? Explain HY: ether layer or water layer? Explain.

In detail, explain how to separate a mixture of naphthalene, byphenyl-4-carboxylic acid, and 4-chloroaniline.

You started with 84g of aniline and 28 ml of acetic anhydride. Give % yield of acetanilide. 653 AM 10/22/2021 B 62PF A D)

Please don't provide handwritten solution

Please don't provide handwritten solution ....

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Sodium borohydride (NABH4) is a very selective reagent. Which functional groups can sodium borohydride reduce? Choose all that apply. O 1. Aldehyde II. Ester III. Carboxylic Acid O IV. Ketone

How do you prepare this solution? 10ml of 20% (w/v) L-arabinose stock (weight/volume). How much of L-arabinose and water do you need to prepare desired arabinose stock

Match the unknowns with their correct class of organic compounds based on the given qualitative tests below.         -              Unknown A           -            Unknown B           -                Unknown C           -            Unknown D  I. acid halide II. ester III. acid anhydride IV. amide

1.OML 3.4ML furan maleic anhydride

EXTRACTION FLOW CHART Draw the appropriate chemical structure (acid, base, neutral, conjugate base, conjugate acid) in the appropriate box in the following flow chart. Copy this into your laboratory notebook as part of the prelab. Indicate if the compound is present in solution or as a solid. Diethyl Ether Solution H₂N- OH benzoic acid Lower Aqueous Layer 6 M NaOH OCH CH₂ 9-Fluorenone Ethyl 4-aminobenzoate (Benzocaine) 3 M HCI Upper Organic Layer 3 M NaOH Lower Aqueous Layer Upper Organic Layer 6 M HCI

What strategy X was used to develop the new drug Y? Select one answer. H₂CO H₂CO X FN-CH3 НО. H₂CO H₂C Oa.X is masking functional groups b.X is extension O c.X is simplification O d. X is rigidification OH N-CH3 Y

Acetic acid, salicylic acid, benzoic acid all of them undergo esterification test separately with n-propyl alcohol and concentrated sulfuric acid. Which among the three is the fastest in showing the formation of pleasant odor. Arrange them from fastest to slowest. Explain and support your answer

LAB 12: SYNTHESIS OF LIDOCAINE Experimental Procedure Step 2: Preparation of Lidocaine, 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide – Step 1- Preparation of N-(2,6-Dimethylphenyl)chloroacetamide 1. To a pre-weighed 50-ml round bottomed flask, add the pressed-dry amide 1 and re-weigh the flask to get an exact amount of amide 1. 1. measure out 3.0 mL of 2,6- dimethylaniline into a 10-mL graduated cylinder and set aside in your hood. 2. sequentially add 7.5 mL diethylamine, 25 mL toluene and a few boiling stones. Attach a water-cooled reflux condenser to the round bottomed flask. 2. measure out 15-ml of glacial acetic acid and add it to a 125 mL Erlenmeyer flask. 3. Reflux the reaction mixture for 60 min. 3. Add the amine (2,6- dimethylaniline), via a Pasteur pipet, to the acetic acid in the Erlenmeyer flask. 4. Cool to room temperature, Transfer to a separatory funnel and wash the organic layer with 3x50 mL portions of 4. Transfer 2 mL of 2-chloroacetyl chloride to the Erlenmeyer…