Case Study diabetes

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Eastern New Mexico University *

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404

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Health Science

Date

Feb 20, 2024

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docx

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1

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Purpose of the study The DPP examined the potential delays or prevention of type 2 diabetes associated with the DPP Lifestyle Change Program  and metformin use. Study Design: What type of Epidemiologic study was conducted? You can find descriptions of study types on pages 56-62 Randomized Controlled Trial (RCT) Total number of participants: What types of participants were included in the group: ethnic make-up, gender, age, etc? What were the three control groups, and how were the participants assigned to each group? From 1996 to 2001, the DPP was a randomized, controlled clinical study carried out at 27 locations across the United States. Three thousand two hundred thirty-four people were enrolled in the study; of them, 55% were Caucasian, and 45% were members of high-risk minority groups for the illness, such as African Americans, Asian Americans, Native Americans from Alaska, American Indians, Hispanic/Latinos, or people from Pacific Islands. Aside from those 60 years of age and above, women with a history of gestational diabetes, and those who had a father, brother, sister, or child with type 2 diabetes, the trial also enrolled additional high-risk populations for the disease. What were two of the outcomes based on the control groups? For example, did the results delay the onset of diabetes? Participants in the DPP Lifestyle Change Program delayed diabetes development by 34%. They developed it four years later, while those aged 60 and older delayed it by 49% and 18%, respectively, compared to placebo participants. Participants in the DPP Lifestyle Change Program and metformin-taking groups improved cardiovascular risk factors, with the latter requiring fewer medications and being cost-effective. At the same time, metformin was found to be cost-saving. For each of the different periods listed below, give one finding about whether diabetes continued to be delayed. Ten year Compared to those who took a placebo, individuals in the DPP Lifestyle Change Program continued to experience a 34% delay in the onset of diabetes, developing the disease around four years later. 15 year Compared to those who received a placebo, individuals in the DPP Lifestyle Change Program continued to enjoy a 27% delay in the onset of diabetes. Go to the Current Focus of this study: Will they continue to fund future studies, and what other health outcomes would they like to study? The NIDDK, in collaboration with NHLBI and NCI, funded a 10-year study to investigate if high-risk individuals taking metformin have lower cardiovascular disease and cancer rates.
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