Abstract
Background and Objectives: Serum creatinine/creatinine clearance despite all its well-known limitations has been the analyte of choice in the assessment of renal function. The possibility of Cystatin C to be a preferred marker of the glomerular filtration rate (GFR) over to the widely used serum creatinine has been suggested1. The aim of this study was to compare the accuracy of Cystatin C with that of serum creatinine in the assessment of GFR in patients with hypertension and diabetes.
Method: Twenty hypertensives and twenty diabetics were compared with forty age-matched healthy controls. Serum ystatin C and serum creatinine were estimated in all study subjects and compared with the actual GFR as estimated by the Cockcroft and
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Thus serum cystatin C appears to be a better marker of renal function, compared to serum creatinine in our patients and controls. The use of cystatin C may be especially useful in cases where creatinine measurement is not appropriate, for instance in patients with liver cirrhosis, obesity and malnutrition, where there is increased muscle protein catabolism.
Studies propose that serum cystatin C is able to predict GFR better than serum creatinine in adult and paediatric populations. The GFR estimated using Cystatin C are independent of age and body composition and are therefore useful in both children and adults, while GFR estimated using creatinine depends on age and obesity. Also, studies reveal that cystatin C methods of analysis may offer better precision than serum creatinine assays 23, 24, 25, 26.
Serum cystatin C’s better performance than serum creatinine in the assessment of GFR may be attributed to its independence on biometric factors like sex, age, and muscle bulk compared to serum creatinine.
According to this study and similar research findings, because Cystatin C has high sensitivity and specificity and because it is not affected by the physiological factors which affect serum creatinine, Cystatin C
2. Which of the lab values gives you information about how Mrs. Burroughs’ kidneys are functioning?
1.1describe the main types of mental ill health according to the psychiatric (dsm/icd) classification system: mood disorders, personality disorders, anxiety disorders, psychotic disorders, substance-related disorders, eating disorders, cognitive disorders
There are also a few tests that will show whether or not the kidneys are filtering the body’s fluids as they should. A simple urinalysis can be done to detect protein or blood in the urine. This will alert the medical professionals to a possible problem with the proper functioning of the kidneys. There are also Blood Urea Nitrogen (BUN), creatinine, and glomerular filtration rate (GFR) tests that will measure the
Creatinine is produced by your muscles as they breakdown creatine, a substance involved in muscle contraction. Creatinine is formed at a constant rate in the body and excreted by the kidneys, so by evaluating the amount of creatinine in your blood, your doctor can determine how efficiently your kidneys are working. Creatinine levels are measured by taking a sample of blood from your vein; then, the concentration of creatinine in your blood is compared to a standard amount for your age and sex. Increased blood creatinine levels may indicate an increase in lupus involvement of the kidney.
No improvement in renal function (decrease in serum creatinine ≤ 1.5 mg/dL or increase in creatinine clearance to ≥ 40 mL/min) following withdrawal of diuretics and expansion of plasma volume with 1.5 liter of isotonic saline.
Similarly, patients with long-standing hypertension with hypertensive retinopathy and a family history of hypertension and CKD are likely to have hypertensive nephrosclerosis, particularly if urinalysis reveals minimal proteinuria and no hematuria22. It is worth noting that the presence of diabetes or hypertension does not rule out another cause of CKD, particularly since hypertension is a consequence of CKD. In addition, distinguishing between diabetic and hypertensive nephropathy is frequently challenging. However, a biopsy is usually not recommended because distinguishing between hypertension and diabetes as the underlying cause of CKD does not change management.
Blood and Urine tests - looking for any indicator of Creatinine kinase which the body produces when muscle breaks down.
Changes in the human environment, behaviour and lifestyle are contributing to the upsurge in the incidence of diabetes. However, better management has resulted in a longer survival of patients with diabetes but it is accompanied by long-term chronic complications due to hyperglycemia 1. Individuals with diabetes most often die of cardiovascular disease (CVD) rather than from a cause uniquely related to diabetes, such as ketoacidosis or hypoglycemia2,3. Diabetic patients have a twofold to sixfold higher incidence of cardiovascular disease than nondiabetic population3,4 Furthermore, diabetic patients with CVD sustain a worse prognosis for survival than CVD patients without diabetes and their quality of life also depreciates. Therefore, diabetes
Serum cystatin C is protein which suggested to be an idea marker of GFR. CKD is a risk factor for dementia. We aimed to determine the serum levels of Cystatin C in patients with CKD and to correlate this with degree of cognitive impairment and stages of kidney disease. 90 subjects aged 65 years and older were involved, divided into two groups; Group (I): 60 patients with CKD, and Group (II): 30 age and sex matched healthy participants. Patients with heart failure, hepatic failure, thyroid disease, patients underwent dialysis for longer than 1 month, patients had polycystic kidney disease, who had bone marrow transplant, and those receiving immunosuppressive therapy with in the past 6 months were excluded from the study. Mini-Mental scale (MMS), serum cyctatin level, stage of CKD were done to all participants. Serum Cystatin level was significantly high in CKD patients. MMS score was significantly lower in CKD patients. A high significant negative correlation was found between serum Cystatin C levels and degree of cognitive impairment. Also a significant positive correlation was found between levels of cognitive impairment and GFR. A high significant negative correlation was found between serum Cystatin C levels and GFR (R=-0.531, p 90 ml/min, to end-stage kidney failure with GFR < 10)
From the evidence recovered it seems to show that the supplementation of quercetin is capable of decreasing blood
Experiment 1: Male and female subjects with short-term (2 months) HFCS access. 150 male and 150 female subjects with comparable BMI levels, daily activity levels and daily medications/vitamins are
“Sometimes when I was starting a new story and I could not get it going, I would stand and look out over the roofs of Paris and think, “Do not worry. You have always written before and you will write now. All you have to do is write on true sentence. Write the truest sentence you know” (shmoop.com). Ernest Hemingway was an honest and noble man. His life was highlighted by his successful writing career that brought him fame, fortune, but ultimately loneliness. Ernest Hemingway fell into a hole of drinking and depression (lib.utexas.edu). It was odd for Hemingway to become so emotionally unstable after having a happy childhood, quality experiences, and a successful writing career.
Chronic kidney disease does not discriminate against age; anyone can get it. However, individuals who have diabetes, high blood pressure, family history, and are of older age are at high risks. However, the earlier the disease is detected, the better the chances are for slowing its progression. The way to check and detect kidney function includes the following: calculation of Glomerular Filtration Rate, an ultrasound or CT scan, and a kidney biopsy ("About Chronic Kidney Disease,"
One of the diseases is diabetes mellitus which is a major cause of renal failure. This disease can be defined as an increase of fasting blood glucose that is affected by a deficiency in insulin hormone. The normal range for glucose (fasting) in the blood is 2.8-6.0 mmol/L. It is classified into two groups, type 1 (insulin-dependent diabetes mellitus) and type 2 (non insulin-dependent diabetes mellitus). Stein (2008, p.6) points out that kidney failure happens most often when patients have suffered from diabetes mellitus for more than 10 years. According to United States Renal Data System (USRDS) report in 2007, approximately 44% of primary causes of renal failure is diabetes mellitus in the United States in 2005. Also, Stein (2008) indicates that 15% of dialysis patients are influenced by diabetes mellitus in the United Kingdom. Diabetes mellitus has negative affects throughout the kidneys where the increase of the range of blood sugar causes the damages to the cells in the kidneys. This leads to the presence of the glucose in the urine which is known as glycosuric.
In this article it speaks about many different types of indicators that one could see in order to determine the ecological state of the wetland by my factors such as the biodiversity, pollution levels, the fauna and flora in the wetland. This relates to our wetland as we have a large biodiversity in our wetland with little pollution as well as plants such as reeds growing which indicate a healthy wetland. We also occasionally see a large variety of birds in our wetland therefore another indicator that our wetland is healthy.