Abstract. Background And Objectives: Serum Creatinine/Creatinine

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Background and Objectives: Serum creatinine/creatinine clearance despite all its well-known limitations has been the analyte of choice in the assessment of renal function. The possibility of Cystatin C to be a preferred marker of the glomerular filtration rate (GFR) over to the widely used serum creatinine has been suggested1. The aim of this study was to compare the accuracy of Cystatin C with that of serum creatinine in the assessment of GFR in patients with hypertension and diabetes.
Method: Twenty hypertensives and twenty diabetics were compared with forty age-matched healthy controls. Serum ystatin C and serum creatinine were estimated in all study subjects and compared with the actual GFR as estimated by the Cockcroft and
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Thus serum cystatin C appears to be a better marker of renal function, compared to serum creatinine in our patients and controls. The use of cystatin C may be especially useful in cases where creatinine measurement is not appropriate, for instance in patients with liver cirrhosis, obesity and malnutrition, where there is increased muscle protein catabolism.
Studies propose that serum cystatin C is able to predict GFR better than serum creatinine in adult and paediatric populations. The GFR estimated using Cystatin C are independent of age and body composition and are therefore useful in both children and adults, while GFR estimated using creatinine depends on age and obesity. Also, studies reveal that cystatin C methods of analysis may offer better precision than serum creatinine assays 23, 24, 25, 26.
Serum cystatin C’s better performance than serum creatinine in the assessment of GFR may be attributed to its independence on biometric factors like sex, age, and muscle bulk compared to serum creatinine.
According to this study and similar research findings, because Cystatin C has high sensitivity and specificity and because it is not affected by the physiological factors which affect serum creatinine, Cystatin C
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