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An Evolving Science New York 2009

Better Essays

Charles Gathathi
BIOL 2420.
Dr. Elizabeth Carrington.
Proteus mirabilis:
I. Introduction:
Proteus mirabilis is a Gram-negative, dimorphic bacillus and a facultative anaerobe bacterium. It is a motile member of the family Enterobacteriaceae. This bacteria colonies shows a unique characteristic called swarming behavior. Swarming occurs when the flagellate rods grow into long chain swarmer cells, the swarmers gather together forming “rafts” that swim together, growing into a complex biofilm. P. mirabilis virulence factors include swarming motility and urease production. Ref: Joan L, John F. microbiology: an evolving science New York 2009, Belas, Schneider and Melch. Journal of bacteriology Dec. 1998 p. 6126-6139.
Its scientific …show more content…

Diseases:
Statistically, about 90% of the proteus infections are caused by proteus mirabilis. It is an opportunist pathogen, which means it can cause diseases if it colonizes another place other than the gastrointestinal tract.
P. mirabilis is commonly associated with urinary tract infections. The infection begins when the organism moves from urethra to the urinary bladder. Urinary tract infections caused by P. mirabilis are mostly found in patients under long-term catherization. Other groups of patients that are at high risks of the diseases include; those patients with structural abnormalities of the urinary tract, patients with recurrent infections and patients whose infections were acquired in the hospital or long-term care facilities.
Proteus mirabilis infections accounts for 1%-2% of urinary tract infections in healthy women, 5% of nosocomial urinary infections and catheterization has a high prevalence of 20%-45%. The organism causes bladder infection and kidney infection. P. mirabilis produces large amounts of urease which splits urea into carbon dioxide and ammonia. This process increases the alkalinity of the urine and also it precipitates magnesium and calcium in the form of struvite and apatite crystals respectively. The results is the formation of renal stones.
Ref: Gus, Gonzales MD medical oncologist: proteus infections Medscape, Murray, Rosenthal, And Pfaller. Medical microbiology 7th edition 2013.

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