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Essay about Cinchona and its Product--Quinine

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Cinchona and its Product--Quinine

The bark of cinchona produces several alkaloids. The most important alkaloid, quinine, has certain febrifuge properties. Quinine was used in the battle against malaria since the 1630's. Of 38 species of cinchona, four species have economic value for the production of quinine: C. calisaya, C. legeriana, C. officianalis and C. succirubra. Cinchona, of the family Rubiaceae, is native to the South American Andes. It thrives best on steep mountain slopes in rich volcanic soils and an annual rainfall of 1,500 cm.(9) The cinchonas flower in 3-4 years. The flowers form small fragrant yellow, white or pink clusters at the end of branches, and are similar to lilacs. The fruits are 1-3 cm oblong capsules with …show more content…

It is not certain who discovered the febrifuge properties-of the bark. The Indians knew of it as a cure for fevers. Although after the Spaniards began its use it was noted that many of the natives refused to use it. It is possible the bark may -have been reserved for royalty. Other natives learned to use powdered bark with lemon juice.

Jesuits also have a claim on discovering the bark. Their method of finding new medicines was by chewing barks. The bark of cinchona is bitter and, therefore, labeled as a medicine. Father John de Lugo took an interest in the bark and undertook the propagation of its use. Because of the Jesuits interest it became known as the Jesuits Powder.

Yet the most famous story behind the discovery involves the wife of a Viceroy of Peru, Countess Ana of Chinchon. In 1638 the Countess contracted malaria while in Peru. She was given a powder that cured her of the fevers. Impressed by this new cure she collected the bark and gave it to others who needed it. However, it is widely disputed that the Countess was responsible for spreading the bark, or that she even had malaria. Nevertheless, Linnaeus named the genus Cinchona in her honor. It is regrettable though that there was an error in the spelling that in 1866 the International Botanical Congress opted to keep.

DOMESTICATION

Acceptance of the cinchona bark was not as immediate as would be expected for an otherwise incurable malady due to past failures with other claims to

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