BACKGROUND: It has been shown that Myeloperoxidase (MPO) is intimately involved in pathogenesis of atherosclerosis and Acute Coronary Syndrome (ACS). Small studies have shown that high levels of MPO are a poor prognostic factor in patients presenting with ACS. However, due to the small nature of these studies, the relationship between MPO and outcomes has not been confirmed. Here we aimed to examine the prognostic value of MPO in patients with ACS.
METHODS: We performed a meta-analysis to compare the long-term prognosis of ACS patients with high MPO and low MPO levels. The literature was retrieved by formal searches of electronic databases (PubMed, EMBASE, Medline, OVID, and web of knowledge) from inception to November 2013. A total of 16…show more content…
The Myeloperoxidase (MPO) is intimately involved in pathogenesis of atherosclerosis and acute coronary syndrome (ACS). Small studies have shown that high levels of MPO are a poor prognostic factor in patients presenting with ACS. However, due to the small nature of these studies, the relationship between MPO and outcomes has not been confirmed. In this systematic review and protocol-driven meta-analysis, we sought to examine the available literature on the prognostic value of MPO among patients with ACS. MATERIALS AND METHODS Review question and study protocol. We report this protocol driven systematic review and meta-analysis according to the Preferred Reported Items for Systematic Reviews and Meta-Analyses (PRISMA)18. Our review question was whether elevated MPO measurement in patients presenting with ACS play a role in long-term prognostication. We performed a meta-analysis to compare the long-term prognosis of ACS patients with high MPO and low MPO levels. Search strategy and eligibility criteria. We searched MEDLINE, the Cochrane databases, EMBASE and CINAHL (Inception to June 2015), using the following database-appropriate Medical Subject Heading terms (MESH): Myeloperoxidase, Acute Coronary Syndrome, Unstable Angina, Non-ST elevation myocardial infarction, prognosis. We sought additional studies by
The Myeloperoxidase (MPO) is intimately involved in pathogenesis of atherosclerosis and acute coronary syndrome (ACS). Small studies have shown that high levels of MPO are a poor prognostic factor in patients presenting with ACS. However, due to the small nature of these studies, the relationship between MPO and outcomes has not been confirmed. In this systematic review and protocol-driven meta-analysis, we sought to examine the available literature on the prognostic value of MPO among patients with ACS. MATERIALS AND METHODS Review question and study protocol. We report this protocol driven systematic review and meta-analysis according to the Preferred Reported Items for Systematic Reviews and Meta-Analyses (PRISMA)18. Our review question was whether elevated MPO measurement in patients presenting with ACS play a role in long-term prognostication. We performed a meta-analysis to compare the long-term prognosis of ACS patients with high MPO and low MPO levels. Search strategy and eligibility criteria. We searched MEDLINE, the Cochrane databases, EMBASE and CINAHL (Inception to June 2015), using the following database-appropriate Medical Subject Heading terms (MESH): Myeloperoxidase, Acute Coronary Syndrome, Unstable Angina, Non-ST elevation myocardial infarction, prognosis. We sought additional studies by
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