Formulation of ICPNP Using Electrostatic Interaction in between SA

1921 Words Jan 31st, 2018 8 Pages
This ICPNP has ability to self assemble in aqueous phase due to hydrophilic and hydrophobic parts present in GCS copolymer 4. The zeta potential of nanoparticle was negative that represents SA present in outer surface of polymeric nanoparticle. This nanoparticle composed of SA and GCS copolymer has four distinct function: i) SA on outer surface provides stability to formulation and sustained release of drug; ii) the GCS part of ICPNP restricts conversion of AmB molecular forms from monomeric to multimeric thus reduces toxicity of the AmB; iii) the ICPNP provides desired localization and biodistribution of AmB in tissues; iv) the SA in outer surface of ICPNP have ability to induce various proinflamatory cytokines and chemokines through macrophage activation via NF-kappaB pathway (Saswat, et al.2104).
The self assembled ICPNP gained significant attention from various researchers as particulate drug delivery system for its ability to encapsulate high drug payload and deliver at target sites 21. There are many reports about PIC nanoparticles but in this study we have prepared self assembled copolymer based ICPNP. The GC was first conjugate with stearic acid in molar ratio of 4:1 to form GCS copolymer 4 that has positive zeta potential measured by zeta sizer on its surface that was referred as cationic polymer. The…
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