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Hodgkin's Lymphoma Case

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Hodgkin’s Lymphoma Introduction Hodgkin’s lymphoma is a cancer that presents as a rare lymphoid neoplasm and primarily involves the lymph nodes.3 It is associated with a good prognosis and survival rates. As a Physical Therapist, it is good to be aware of the signs and symptoms, and their implications for therapy.
Pathophysiology
Hodgkin’s lymphoma is pathologically associated with Reed-Sternberg cells.3 As explained by Yung and Linch, Reed-Sternberg cells are classified as clonial lymphoid cells that are of B-lineage.11 The transformation of a B-cell to a malignant Reed-Sternberg cell is still under speculation, but it is most likely believed to be associated with infection, inflammation, or reaction to the Episteme
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There are three main subtypes of this disease and two main categories of presenting signs and symptoms that help to distinguish between early-stage and advanced-stage disease. The three main subtypes are Classic Hodgkin’s Lymphoma, Nodular Sclerosing Hodgkin’s Lymphoma and Mixed Cellularity Classic Hodgkin’s Lymphoma. Classic Hodgkin’s Lymphoma typically affects lymph nodes in the cervical, supraclavicular, and mediastinal regions and are non-tender but firm.3 Nodular Sclerosing Hodgkin’s Lymphoma affects the lymph nodes in the supradiaphragmatic region. Mixed Cellularity Hodgkin’s Lymphoma affects the lymph nodes and organs in the subdiaphragmatic region and these individuals typically present with B-symptoms. There are 2 main categories of presenting signs and symptoms are B and Non-B symptoms. Non-B symptoms, are those associated with early-stage, and consist of fatigue, pruritus, and pain when drinking alcohol. On the contrary, B-symptoms, are those associated with advanced-stage disease, and consist of fever, drenching night sweats,9 spleen enlargement,3 and a 10% decrease in body weight over 6…show more content…
According to Gobbi et al., the standard treatment for individuals with early-stage Hodgkin’s Lymphoma involves 6 cycles of ABVD (adriamycin, blemycin, vinblastine, and dacarbazine) chemotherapy, with or without involved-field radiation.2 Individuals are administered this treatment in short bursts.2
In more advanced stages of Hodgkin’s lymphoma, the same treatment regimen is used except commonly with a more aggressive chemotherapy drug regimen of BEACOPP (blemoycin, etopside, doxorubicin, cyclophosphamide, vincristine, prednisone, and procarbazine) instead of ABVD.2 Individuals are also administered this treatment more frequently, typically weekly, depending on the extent of metastasis that has occurred and the location of the
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