HPV-associated anal and oral cancers are increasing. The reason is still unclear although sexual behavior changes in the general population are postulated as one of the factors. The incidence is drastically higher in specific risk groups, such as men who have sex with men, and HIV-1 infected individuals. Interestingly, anal cancer is predominant in women while a higher incidence of oral cancer is found in men. This review gives a brief summary of epidemic, risk factors, mechanisms, diagnosis, and treatment of these two HPV-associated cancers.
Most sexually active individuals will have detectable human papillomavirus (HPV) at least once in their lifetime. 14 million people are infected annually, and 79 million people have the prevalent infection. Approximate 5% of the cancers globally are HPV-associated anogenital or oral cancers (1). HPV is transmitted frequently between partners; more frequent transmission has been reported from females to males than from males to females (2). The incidence of anal and oral cancers related to HPV is increasing in the general population and is growing even faster among individuals who are immunocompromised because of human immunodeficiency virus (HIV) infection (3, 4). Two prophylactic vaccines (Gardasil and Cervarix) have been approved for a decade. Recently, the nonavalent vaccine including additional high-risk HPV types is promised to provide more coverage against cervical cancers (5). The HPV vaccine is recommended
HPV is so common in the United States that nearly all men and women will contract the virus at some point during life (Center for Disease Control and Prevention [CDC], 2017). In the United States, in 2008, it is reported that 3.2 million, or one in four adolescent women, ages 14 to 19 have had or have an STD (Kostas-Polston et al., 2012). The rate of HPV cases has only increased since 2008. The prevalence of a genital infection with any HPV type was 42.5% among United States during 2013–2014 (CDC, 2017). The incidence of HPV in the United States is about 14 million people each year.
Prophylactic vaccination against high risk human papilloma virus 16 and 18 represents an exciting means of protection against HPV related malignancy. However, this strategy alone, even if there is a level of cross protection against other oncogenic viruses, cannot completely prevent cervical cancer. In some countries cervical screening programs have reduced the incidence of invasive cervical cancer by up to 80 percent although this decline has now reached a plateau with current cancers occurring in patients who have failed to attend for screening or where the sensitivity of the tests have proved inadequate. Cervical screening is inevitably associated with significant anxiety for the many women who require investigation and treatment following abnormal cervical cytology. However, it is vitally important to stress the need for continued cervical screening to complement vaccination in order to optimize prevention in vaccines and prevent cervical cancer in older women where the value of vaccination is currently unclear. It is likely that vaccination will ultimately change the natural history of HPV disease by reducing the influence of the highly oncogenic types HPV 16 and 18. In the long term this is likely to lead to an increase in recommended screening intervals. HPV vaccination may also reduce
Almost all cervical carcinomas are caused by Human papillomavirus (HPV). Cervical cancer can be a life-threating disease. However, over recent years the occurrence of cervical cancer has declined as well as the chance of dying from it. A huge contributing factor to this decline is the importance of a regular pap smear. A pap smear can find cervical pre-cancer before it turns into cancer. Recently, a vaccine for HPV, has been on the market, which provides close to a 100% protection against pre-cancer and general warts. HPV and cervical cancer are two disease that are closely related. However, each disease effects not only similar populations, but also different populations, as well as having its own signs and symptoms, detection procedures,
Human Papilloma Virus, more commonly known as HPV, is a sexually transmitted virus. It is spread from skin-to-skin contact with an infected person, typically during sexual encounters. It is the most common sexually transmitted disease in the United States. According to the Immunize Action Coalition, “most sexually active American men and woman will contract at least one type of HPV virus during their lifetime” (A Parent 's Guide to Preteen, 2013, p. 1). To put the numbers in perspective, it infects an estimated seventy-nine million Americans today with approximately fourteen million more people being affected additionally each year (Human
Human Papillomavirus(HPV) is the most common sexually transmitted infection in the United States, according to Centers for Disease Control and Prevention(CDC) around 20 million people are infected with HPV and additional 6.2 million people are newly infected every year. According to National Health and Nutrition Examination Survey in 2003-2004 among sexually active women (57% of 14 to 19 years and 97% of 20 to 59 years) HPV was highest prevalent in youngest age group (40% of 14-19 years and 50% of 20-24 years). Infection rates decrease after age of 24 years. There are more than 100 types of HPV viruses out of which 40 cause genital infections. Out of
According to the National Cancer Institute, not all human papillomaviruses (HPV) cause cancer. There are two types of categories; the low risk and high risk human papillomaviruses. If one contracts a high risk HPVs, they have a chance of developing cancer. High risk HPVs can lead to cervical cancer, anal cancer, oropharyngeal cancer, vaginal cancers, vulvar cancers, and penile cancers (1). The National Cancer Institute states that HPVs account for causing 5% of cancers and Nathan Seppa proclaims “that the two cancer-causing virus subtypes... HPV-16 and HPV-18, account for more than half of cervical cancers” (1 and 2). This demonstrates the overall impact HPV has on causing cancer.
Human Papillomavirus (HPV) is a double -stranded deoxyribonucleic acid (DNA) virus that only infects humans with an attraction to both cutaneous and mucosal surfaces such as the cervix, anus, tonsil, and oropharynx (Clark, 2013). HPV is a type of oncogenic virus that goes into the cells and can cause several diseases. Over the years, research has surfaced connecting genital HPV to several types of cancer. There are over a hundred strains of HPV but the most high risk strains, 16 and 18, have been shown to cause vulvar, vaginal, anal, and the most concerning, cervical cancer (Chan, Ng, & Wong, 2012). Genital HPV
Human papillomavirus (HPV) is made up of double stranded DNA with a capsid. Their viral genome is consisting of such as early (E) gene like E6 and E7encodes for oncoproteins and late (L) gene such as L1 and L2 encodes for structural proteins like capids. There are more than 100 different types of HPV identified and they generally infect around cutaneous or mucosal areas. HPV viral genome can be categorized into low risk (LR) and high risk (HR). High risk types such as HPV-16 and -18 are ones that can develop into cancer and other tumors mostly in genital area or a head and neck squamous cell. Low risk types such as HPV-6 and -11 are more frequently found I larynx or genital area (Klozar et al., 2010). Therefore, careful evaluation such as risk factors, or possibly a new vaccination to prevent against HPV related to oropharyngeal SCC should be questioned in public health
Cervical cancer is formed in the tissues of the cervix, an organ that connects the uterus and the vagina. Virtually all cervical cancers are caused by Human papillomavirus (HPV) infections (Schiffman et. al., 2007). HPV is the most common sexually transmitted infection in the United States. According to the CDC, 75% of sexually active people aged 15-49 have the infection at some point in their lives. (CDC). Because HPV infection is usually asymptomatic, infected people do not know exactly when they get the infection. In most cases, the body is able to fight off the virus before any symptom. However, health problems such as genital warts and cancer may
Human papillomavirus (HPV) is the most common sexually transmitted disease (STD) and can affect many sexually active individuals throughout their lifetimes and is spread through anal, oral and vaginal sex (CDC, 2016). HPV currently affects 79 million Americans with 14 million new cases of infection every year and is so pervasive most sexually-active individuals will encounter some form of the virus during their lives (CDC, 2016). HPV can be troublesome to detect as symptoms can develop years after initial infection or may not be seen at all, but in many cases HPV does not cause lasting health problems (CDC, 2016).
Among the 12, 200 new cases of cervical cancer ninety-percent of them are caused or attributed to HPV.
Human Papillomavirus (HPV) is a sexually transmitted virus that spreads from person to person by direct contact of infected tissue. According to the CDC, nearly all men and women will contract HPV at some point in their life (Centers for Disease Control and Prevention [CDC], 2013). HPV can cause cervical, vaginal and vulvar cancers in females. HPV can also cause anal, throat, and neck cancer in both males and females. HPV is also known to cause genital warts in both males and females. According to the National Cancer Institute (2013), “approximately 12,340 new cases of cervical cancer will be diagnosed in the US, and 4,030 US women will die
HPV, human papillomavirus is a communal infection that is common among adults. It is one of the main sources of sexual transmitted infection. Over 75% of women that are sexually active are most likely to be infected at least once in their life. This virus is known to be a worldwide disease. According to the World Health Organization, the risk of acquiring HPV infection is highest soon after a sexual encounter. Most of these infections are self-limiting and harmless. The virus is harmless because a number of people don’t realize they are infected, because the virus is often subclinical. Persistent infections with oncongenic HPV types can cause cervical cancer in women. Even though, both male and female can be affected by the
Human Papilloma Virus (HPV) is one of the most common sexually transmitted infections in the United States. HPV belong to a family of viruses that cause cell changes in the epithelia resulting in benign skin lesions called warts and verrucae. Type 6 and 11 cause warts and are included under the low risk HPVs,Types 16,18,31,33,45 cause cervical cancer and are included under high risk HPVs(CDC,2014). The virus affects the skin and mucous membrane especially of the reproductive organs. Cervical Cancer and other Ano-genital cancers are seen in women with persistent genital HPV infection. HPV that affects the skin can be transmitted by skin to skin contact with an affected person and Genital HPV is spread through Kissing and Oral
Human Papilloma Virus (HPV) remains the most commonly sexually transmitted infection in both males and females. (Giuliano et al., 1999).