Identification Of Conserved Regulatory Motif

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Identification of Conserved regulatory motif signatures in Human miRNA upstream regions

Pankaj Kumar Singh1, Jayita Roy(nee Ghoshal)1
Dept. of Anthropology
Narasinha Dutt College
Howrah – 711101, West Bengal, India

Protip Basu2, Vineet Vishal2, Abhisek Ranjan Bera2, Abhaydeep Pandey2, Rahul Banik 2
Bioinformatics Division
The Biome
Kolkata-700064, West Bengal, India

Sayak Ganguli3
Theoretical and Computational Biology Division
Amplicon Biosciences (P) Ltd.,
Palta-743122, West Bengal, India

Abstract—Discovering and characterizing regulatory elements of miRNA genes are fundamental problems in bioinformatics field. An upstream regulatory motif can be described as a sequence element designated for binding of various protein factors imparting their subsequent effects on the transcription of the genes. For example, the transcription factors often bind to cis-acting conserved motif to regulate transcription, which typically are located upstream of transcriptional start sites .This work focuses on the identification of upstream regulatory elements of human microRNA genes by screening of their Kullback Liebler distance
Keywords— TFBS, non protein-coding, transcription factors, promoter, Kullback – Liebler distance,big data.
INTRODUCTION
It was in the year 1990 that transgenic introduction of a gene silenced endogenous gene expression in plant (Petunia) was first achieved by the introduction dsRNA. It was found that it is processed by Dicer into a 21-23nt small
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