Identification Of Conserved Regulatory Motif

1260 WordsJan 22, 20166 Pages
Identification of Conserved regulatory motif signatures in Human miRNA upstream regions Pankaj Kumar Singh1, Jayita Roy(nee Ghoshal)1 Dept. of Anthropology Narasinha Dutt College Howrah – 711101, West Bengal, India Protip Basu2, Vineet Vishal2, Abhisek Ranjan Bera2, Abhaydeep Pandey2, Rahul Banik 2 Bioinformatics Division The Biome Kolkata-700064, West Bengal, India Sayak Ganguli3 Theoretical and Computational Biology Division Amplicon Biosciences (P) Ltd., Palta-743122, West Bengal, India Abstract—Discovering and characterizing regulatory elements of miRNA genes are fundamental problems in bioinformatics field. An upstream regulatory motif can be described as a sequence element designated for binding of various protein factors imparting their subsequent effects on the transcription of the genes. For example, the transcription factors often bind to cis-acting conserved motif to regulate transcription, which typically are located upstream of transcriptional start sites .This work focuses on the identification of upstream regulatory elements of human microRNA genes by screening of their Kullback Liebler distance Keywords— TFBS, non protein-coding, transcription factors, promoter, Kullback – Liebler distance,big data. INTRODUCTION It was in the year 1990 that transgenic introduction of a gene silenced endogenous gene expression in plant (Petunia) was first achieved by the introduction dsRNA. It was found that it is processed by Dicer into a 21-23nt small
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