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Introduction To Nursing Research And Evidence Based Practice

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Introduction to Nursing Research and Evidence Based Practice Working in the oncology field can be challenging, yet very rewarding. Chemotherapy is used to destroy cancer cells, however, chemotherapy attacks all cells, good and bad. Because of this, patients going through chemotherapy often experience chemotherapy-induced neutropenia. This leaves the patient extremely susceptible to infection, and often affects the patient’s ability to receive their chemotherapy regimen. In chemotherapy-induced neutropenia, how does the use of granulocyte colony-stimulating factor(s) (G-CSF), compared to not using them, influence the risk of developing severe neutropenia during chemotherapy. Chemotherapy-induced neutropenia is a very common problem that …show more content…

Because granulocyte colony-stimulating factor(s) (G-CSF) work on the bone marrow, patients often complain of feeling pain in their bones, such as their pelvis. These drugs come in the form of an injection, and are given in the subcutaneous fat in the abdomen or back of the arm. They can be a very good option for patients under active treatment that drop their counts after chemotherapy. Infections in neutropenic patients can progress very rapidly, with minimal signs and symptoms, due to the inability for the body to produce inflammatory responses (Wingard, 2016). With neutropenic patients, life-threatening complications can happen, thus granulocyte colony-stimulating factors can be used for first and second line neutropenic prevention (Larson, 2017). Before administering G-CSF, a patient’s chemotherapy regimen and neutropenic risk must be weighed to ensure that G-CSF is appropriate and necessary. For example, if a patient is over the age of 65 and the chemotherapy regimen they are ordered is high risk (>20%), G-CSF therapy is appropriate and should be given (Aapro, 2010). Similarly, if a patient has required G-CSF before due to chemotherapy-induced neutropenia, the patient should always receive it in the future with chemotherapy (Aapro, 2010). G-CSF is also appropriate in dose-dense chemotherapy strategies, where survival is the end goal of treatment (Aapro, 2010). In a study done on the

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