Lab Report On Aspirin

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The purpose of this lab experiment is to study a simple esterification reaction, producing acetylsalicylic acid (aspirin), thus becoming familiar with synthetic chemistry tools and techniques.

Organic molecules can be classified based on the functional groups that they possess. One of these classes is esters, which are produced from an acid and an alcohol as shown in the following figure.

Figure 1: Reaction of a carboxylic acid and an alcohol to form and ester.2
Based on the above reaction, a wide variety of esters can be formed since there are so many acids and alcohols that could be combined. Typically, the resultant is an equilibrium mixture containing the ester, the water, the acid and the alcohol.

In this lab
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3. Place the Erlenmeyer flask into the hot water bath and gently swirl. The solution will liquefy and crystals of acetylsalicylic acid will start to form. Remove the flask from heat once crystal formation begins and take note of the smell.
4. Allow the flask to cool down to room temperature on the lab bench before placing it into the ice-water bath.
5. Break up the crystals with a glass stir rod and slowly add 20 mL of pre-cooled distilled water to destroy an unreacted acetic anhydride. Cool the flask for several minutes to get as many crystals as possible.
6. Use vacuum filtration to collect the ASA crystals. Wash the crystals using about 10 mL of ice cold water three times. In order to allow the cold water to destroy impurities in the crystals, momentarily disconnect the tubes to reduce suction rate before allowing the water to be filtered out.
7. Transfer the crystals to a pre-weighed watch glass, break them up and spread them out, then place them into the oven for approximately 10 minutes.
8. Record the mass of the watch glass and the crude product, wait 5 minutes and then weigh the sample again.
Part II Recrystallization5
1. Weigh approximately 1 g of crude ASA into a 150 mL beaker. Put about 30-35 mL of distilled water into a 50 mL beaker and bring it to a boil. Use tongs to hold the beaker and pour approximately 10 mL of the boiling water into the beaker containing crude ASA.
2. Place the beaker with the crystals onto the hot plate and only keep it hot enough so
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