On October 7th 2013, the Nobel Assembly at Karolinska Institutet awarded the 2013 Nobel Prize in Physiology or Medicine jointly to James E. Rothman, Randy W. Schekman and Thomas C. Sudhof for “their discoveries of machinery regulating vesicle traffic, a major transport system in our cells”. Before this research, knowledge about the vesicle transportation system that eukaryotic cells utilized was essentially limited to what could be observed, including its various tasks and actions and its huge significance