Reaction Paper On Rutin

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Abstract: Rutin (R) is a citrus flavonoid glycoside found in many plants having biological and pharmacological effects such as anti-oxidative, anti-inflammatory, anti-carcinogenic, and antimicrobial, etc. In this work we have analysed the interactions of rutin with normal human hemoglobin (HbA) using UV-Visible spectroscopy, steady state fluorescence spectroscopy, time-resolved fluorescence spectroscopy, synchronous fluorescence spectroscopy and molecular modeling studies. Specific interactions of the flavonoid, Rutin, with human hemoglobin has been confirmed from flavonoid-induced static quenching which is evident from steady-state fluorescence as well as lifetime data. Molecular docking study reveals that apart from hydrogen bonding and…show more content…
Rusznyák and A. Szent-Györgyi were the first scientists who described the therapeutically benefits of a type of flavonoids, which were then named “vitamin P” [1]. Flavonoids are plant phytochemicals that cannot be synthesized by humans. More than 4,000 flavonoids have been identified. Flavonoids are the known to be the largest class of polyphenols, they can be classified into 6 subclasses i.e. flavones, flavonols, flavanones, catechins, isoflavones and anthocyanidins. Structurally, flavonoids are usually characterized by a C6-C3-C6 carbon skeleton. Flavonoids occur as aglycones (without sugar moieties) and glycosides (with sugar moieties). [2] Flavonoids have attracted the attention of researchers because of its anticancer, antiviral, anti-inflammatory, and heart disease protective activities…show more content…
Docking simulation techniques were performed using Glide module (Schrödinger software suite) with HbA (PDB ID: 2D60) obtained from Protein Data Bank and a plant flavonoid rutin 3,3',4',5,7-pentahydroxyflavone-3-rutinoside). For validating the software the protein was redocked with a already bound ligand. The docking score ( or G score) of rutin was found to be -6.251, as the best G-score is obtained as the most negative value, thus we can say -6.251 is a a very good docking

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