The Role Of Genetic Factors And Contribution To The Risk For Type 2 Diabetes

There are several factors, however, that can increase a person's risk of developing type 2 diabetes. Primary concern and cause of type 2 diabetes is obesity or overweight, people over the normal weight baseline of the BMI spectrum. America has always been known as the country that is two/thirds obese and many of American habits contribute to the following daily bad decisions that seem related to type 2 diabetes. Poor eating habits are the number one cause of obesity and type 2 diabetes, choosing to eat bad food and lots of soda can have tremendous effects on your weight and glucose intake. Watching too much television (T.V.) is another related issue towards diabetes, most likely eating snacks while watching your favorite show or movies. Physical inactivity causes the body to have a high blood glucose causing diabetes; muscles use the glucose through physical activity by helping the hormone insulin absorb glucose into all your body cells. Your muscles use glucose better than it uses fat. Sleeping habits such as sleeping less than 5 hours or more than 9 hours a night can affect the body’s balance of insulin and increase the demand on the pancreas to make it. Lastly, genetics has played a big role in determining if a person is at risk for type 2 diabetes. Your risk is higher if your brother, sister, or parent have type 2 diabetes. Genetics is a factor that is out of our control and it is

(2012) suggest that, “genetic ancestry has a significant association with type 2 diabetes above and beyond its association with non-genetic risk factors for type 2 diabetes in African Americans, but no single gene with a major effect is sufficient to explain a large portion of the observed population difference in risk of diabetes. and that there is a interplay among specific genetic factors, which may both be associated with overall admixture, leading to the observed ethnic differences in diabetes

While only 7.6 percent of non-Hispanic whites and 9 percent of Asian-Americans have diabetes, 12.8 percent of Hispanics have diabetes. Other high-risk ethnic groups are non-Hispanic blacks (13.2 percent) and American Indians/Alaskan Natives (15.9 percent). For Hispanics living in the United States, the prevalence of type 2 diabetes is lower in those coming from Central and South America (8.5 percent) or Cuba (9.3 percent), but higher for those who are Mexican American (13.9 percent) and Puerto Rican (14.8 percent), who comprise the majority of Hispanic immigrants in the U.S. (Valencia, Oropesa-Gonzalez, Hogue & Florez,

Type 2 diabetes mellitus (T2D) is the most common form of diabetes (American Diabetes Association, 2012). T2D is so prevalent that it is estimated to be the fifth most common cause of death worldwide (Yates, Jarvis, Troughton, and JaneDavies, 2009, p. 1). T2D manifests when the body is unable to metabolize glucose properly, resulting in elevated blood sugar, debilitating fatigue, and other serious complications such as distal limb amputations, kidney failure, and blindness. The generally accepted causes of T2D include diet, sedentary lifestyle, and obesity.

The proband’s family history consist of both type 1 and type 2 diabetes; especially the females within her maternal linage. Family histories where type 1 and type 2 diabetes co-occur happens often (Nogueira, 2013). Both types of diabetes are caused by a loss of physical or functional beta cell mass (Nogueira, 2013). Type 1 diabetes (T1D) is due to an autoimmune process and type 2 diabetes (T2D)

The increase in the prevalence of type 2 diabetes is causing huge health problem through out the world including developed countries. Mostly people with low income groups are affected in developed countries (Zimmet 2001).The magnitude of the healthcare problem of type 2 diabetes results mainly from its association with obesity and cardiovascular risk factors. Indeed, type 2 diabetes has now been identified as one manifestation of the “metabolic syndrome”, a condition characterised by insulin resistance and associated with a range of cardiovascular factors (Jonathan 2003)

First, for Latinos, studies have found that the prevalence of total diabetes, diagnosed and undiagnosed, among all Hispanic/Latino groups was roughly 16.9 percent of both men and women, compared to 10.2 percent of non-Hispanic whites. However, when looking at Hispanic/Latino groups individually, it found that prevalence varied from a high of 18.3 percent for those of Mexican descent to a low of 10.2 percent for people of South American descent. The study showed 18.1 percent of people of Dominican and Puerto Rican descent; 17.7 percent of Central American descent; and 13.4 percent of Cuban descent living in the United States had type 2 diabetes (Alexandria, 2014). As people believe, also prevalence rose dramatically with age, reaching more than 50 percent for Hispanic/Latino women by the time they reached age 70 and 44.3 percent for men aged 70-74.

In the assigned reading article, researchers propose that minority populaces are at higher risk for diabetes than the social majority. This risk is directly linked to a decreased sense of educational attainment and high levels of

The burden of Type diabetes is much higher in ethnic minorities than for whites (CDC, 2011). Those of which include Latino and African American ethnicities. According to Lemon, Rosal, & Welch (2011), Latinos have a higher rate of type 2 Diabetes Mellitus rates than Caucasian because of socioeconomic status, education, health beliefs, family/relationship, and gender role expectations. The majority of this literature review was women and most of which had less than 8 years of education, with the average income of less than $10,000 annually (Lemon, Rosal, & Welch, 2011). Both of these factors which contribute to the risk of prevalence of Type 2 Diabetes. Several factors including language, literacy, and culture and values all are important in addressing the risk factors in low-income Spanish speaking individuals’ quality of life and risk of chronic disease.

Diabetes is continuing to progress in minorities and published in 2011 indicate that about 26 million Americans have diabetes, or about 8.3% of the US population. An additional, 79 million Americans have pre-diabetes, placing them at high risk for developing type 2 diabetes. (Hill J, Galloway JM, Goley A, et al. 2013). The public health burden of diabetes is even more evident in most racial and ethnic minority groups. The prevalence of type 2 diabetes and other comorbidities, including mortality, are higher for African Americans and Hispanics, the largest racial/ethnic minority groups in the US. Despite the reported successes seen in several national diabetes prevention and control studies, there is still more to be done to understand the best mechanisms for translating the results to patient care ( Spruill, IJ, Magwood GS, Nemeth, L. S & Williams, TH

Braun tells me that there are possibly a million SNPs in each person, though only a small fraction are tightly linked with common ailments. These disease-causing SNPs are fueling a biotech bonanza; the hope is that after finding them, the discoverers can design wonder drugs. In the crowded SNP field, Sequenom vies with Iceland-based deCode Genetics, American companies such as Millennium Pharmaceuticals, Orchid

Another article related to the gene theory titled Genetic and Environmental Factors Associated with type two Diabetes and Diabetic Vascular Complications conducted in 2012 by Murea, MA, and Freedman. This study focused on exploring secondary data to find what researchers have found about the relationship between genes and diabetes, and environmental factors and diabetes. This study focused more on type two diabetes and how it relates to vascular complications. It concentrates on how finding the relationship between genes and diabetic can help finding treatment option for the disease prevention or delay in the disease progression (Murea & Freedman, 2012). The authors also review and article that reviewed the literature supporting genetic determinants in the

Type 1 diabetes is an autoimmune disorder, in which the pancreas does not produce insulin. It usually begins in childhood or adolescence. In Type 1 diabetes, the body’s immune system destroys beta cells in the pancreas that produce insulin. Insulin is a hormone that converts sugar, starches, and food into energy. Without insulin, blood glucose levels become too high, which is known as hyperglycemia. To prevent hyperglycemia, people with Type 1 diabetes must take insulin daily to survive. Genetic and environmental factors affect the onset of Type 1 diabetes. [1] According to the American Diabetes Association, a predisposition to Type 1 diabetes is

Type 2 diabetes is known to affect 11.8% of the Hispanic population compared to 7.1% of non-Hispanic Whites (Gonzalez, Berry, & Davison, 2013). As of July 1, 2013, the Hispanic population is the largest minority group in the United States (CDC, 2013). This statistic, combined with the high prevalence of diabetes in the Hispanic population makes diabetes self-management a priority (Gonzalez et al., 2013). Hispanics are more likely to develop end-stage renal disease related to diabetes and they are also 50% more likely to

There are several risk factors which can contribute to a person developing Type 2 Diabetes. These are: Family history i.e. a first degree relative (Mother, Father, Sibling) who has diabetes. Age – middle age (over 40) onwards or over 25 if Asian. Obesity – once a person is classed as obese (over 20% above ideal bodyweight). Waist circumference – men over 37 inches and women over 311/2 inches. Ethnicity – Type 2 diabetes is more prevalent in the Asian, African-Caribbean or Black African community. Diabetes.org.uk (2017) states ‘Type 2 diabetes is 2 to 4 times more likely in people