Introduction An alcohol is composed of a hydroxyl group attached to a saturated carbon atom. Alcohols on a molecular level can be transformed into alkenes. For this reaction to occur, the alcohol must be dehydrated. Alcohols are capable of being transformed under two known reaction mechanisms, E1 and E2. These mechanisms allow for the dehydration of water and the formation of a double bond which is created into a synthesized alkene. The dehydration of an alcohol can occur in one of two ways. The first way is through being acid catalyzed. This reaction occurs when the acid is presented, and interaction is presented between both the acid and the potential leaving group. As known the hydroxy group is unstable, and not a good leaving group, therefore is needed to be protonated for the detachment of the hydroxy group to take place. In base promoted dehydration, the second method of transforming an alcohol to an alkene, is based on the same concept. The leaving group must be turned stable to be able to become a good leaving group. The difference between the two possible reactions is that base promoted is not reversible. It is not able to be reacted with the alkene in the opposite process. In addition, base promoted and E2 elimination reactions are favorable only when the acidic medium is not able to proficiently complete the reaction. In times when the acid is not able to proceed the reaction, there are certain factors that are used that are able to yield desirable products. Issues seen when a molecule is reacted with a strong acid unexpected rearrangement of carbocations can arise. Moreover, double bond migrations can appear sometimes in the presence of strong acids; however, because this is able to occur during hydrogenation, a base can reduce the occurrence of the migration. There are also changes in the stereochemistry that can possibly occur, as well as side reaction materials such as ethers. When these issues are faced, base promoted elimination is a better way for the reaction to be continued. As previously mentioned, acid catalyzed as well as base promoted must be able to create the hydroxy group into a good leaving group by protonation. According to base promoted reactions, the base that is consumed is
6. Summarize in a few sentences the halogenation and controlled oxidation reactions of 1°, 2°, and 3° alcohols.
Abstract: Using hypochlorous acid to convert secondary alcohol called cyclododecanol to the corresponding ketone which is cyclododecanone by oxidation.
Using SN1 reaction mechanism with hydrochloric acid, t-Pentyl alcohol was converted to t-Pentyl chloride in an acid catalyzed reaction. The reaction took place in a separatory funnel designed to separate immiscible liquids. The crude product was extracted by transferring a solute from one solvent to another. The process of washing the solutions by phase transfer was used in order to remove impurities from the main solvent layer. Finally, the crude product was dried with anhydrous Calcium chloride and purified once more by simple distillation technique.
The purpose of this lab was to carry out a dehydration reaction of 2-methylcyclohexanol by heating it in the presence of phosphoric acid and determining which alkene product would be the major product. Methylcyclohexanols were dehydrated in an 85% phosphoric acid mixture to yield the minor and major alkene product by elimination reaction, specifically E1. The alkenes were distilled to separate the major and minor products and gas chromatography was used to analyze the results and accuracy of the experiment. The hypothesis was the major product of the reaction would be the most substituted product. This conclusion was made because of
The solution that was performed in this experiment was to use sulfuric acid in order to form a protonated alcohol, so when the halogen or nucleophile back attacks the compound, water is displaced. Once the alcohol is protonated, the solution reacts in either an SN1 or SN2 mechanism.
The purpose for the experiment was to perform a dehydrogenation reaction. The experiment showed when ADH was the most productive with four substrates ethanol, butanol, propanol, methanol and different temperatures and pH levels. In order to perform a dehydrogenation reaction there should be a product and a substrate. There are two protons that were removed one proton went into the reduced form NADH that formed and the other proton was released which in return makes the reaction. The problem under the experiment was determining which temperature and pH level was most affective at one substrate for the enzyme ADH and what substrate was most effected by
When water and DNA interact, a hydration shell forms around the DNA (which is made up of nucleic acids), as both the sugar-phosphate backbone of the DNA as well as the water are polar and so they attract each other. When salt is present in the solution, is dissociates into its ions; Na⁺ and Cl⁻. The hydration shell blocks the positive sodium ions from interacting with the negatively charged phosphate backbone. When ethanol is added, which is less polar than both the water and DNA, it disrupts the hydration shell. This allows the sodium ions to interact with the phosphate backbone causing the DNA to precipitate out of the solution, with the salt.
There is a class of related enzymes known as Phenolases. These enzymes catalyze the oxidation of compunds that have hydroxyl groupds attatched to a benzene ring, recongized as phenols. The enzyme is shown to be nonspecific and capable of oxidizing Substrates with acidic side chain are oxidized less effectively having the possibility of denaturing the enzyme. The substrate within the enzyme is oxidized, or combine or become combined chemically with
Alcohol is a diuretic. Diuretics are medicines which cause the removal of water from body. They are able to achieve this by increasing the amount or volume of urine your kidneys produce. The amount of water which is absorbed from the loop of Hénle is greatly reduced as the concentration of Na+ remains in the filtrate, this prevents the water being drawn into the renal medulla. Normally in the case of diuretic drugs, this would decrease the total blood volume in the body, giving your heart less work and reduce blood pressure, making diuretics a choice drug for heart failure and high blood pressure. Alcohol reduces the production rate of vasopressin, which also acts on the kidneys, decreasing the amount of water reabsorbed into the body. All
Firstly, a reaction that is catalyzed by the enzyme fatty acid ethyl ester (FAEE) synthase leads to the formation of molecules known as FAEEs (Zakhira, n.d.). The second nonoxidative pathway requires the enzyme phospholipase D (PLD) which breaks down phospholipids and forms Phosphatidic acid (PA). Additionally, the oxidative and nonoxidative pathways of alcohol metabolism are interrelated. As a result, the inhibition of ethanol oxidation by compounds that inhibit ADH, CYP2E1, and catalase produces an increase in the nonoxidative metabolism of alcohol (Zakhira,
The article I chose talks about the effects of dehydration on the body. The first example, put simply, is if a human loses 2% of their body mass in water, then your kidneys will send less water to the bladder and stop producing sweat. This follows the first rule of logic because if the body did not lose that amount of water, then the body would function normally. It follows the second rule of logic because these are the results of scientific studies, meaning that these are the effects observed in most, if not all, cases. All events included are necessary for the result. The second example I chose states that if the human body sweats less, then the internal body temperature will increase. This follows the first rule of cause and effect because
The investigation stage of this report will focus on comparing fermentation and hydration as methods on producing ethanol. The report will detail each method on their physical production, hazards, environmental impacts and global production. From this the author will gain a clear understanding on each key area and then form a
After the alcohol in the alveolar is exhaled, a breathalyzer can detect the blood alcohol content of the individual. Lastly, the liver takes care of whatever alcohol is left in the body. Alcohol in beverages is known as ethyl alcohol, more commonly known as ethanol. This ethanol is chemically broken down in the liver. The enzyme, alcohol dehydrogenase, strips electrons from the ethanol to form acetaldehyde. Another enzyme, aldehyde dehydrogenase, with the help of oxygen, will convert the acetaldehyde into acetic acid. The acetic acid can be used for to form fatty acids or if further broken down into carbon dioxide and water.
Water is an essential part to maintaining a healthy body and weight. Without the proper intake of water, the body becomes dehydrated and it begins to pull it from other places including from your blood. “This causes the closing of some smaller vessels (capillaries), making your blood thicker, more susceptible to clotting, and harder to pump through your system. This can have serious implications in hypertension, high cholesterol, and heart disease. Recent studies have also linked the lack of water to headaches, arthritis, and heartburn.” (TheraGear 2001)
The homogeneous molecular structures of alcohol systematically change with increase in the number of the carbon atoms, the hydroxyl group (–OH) and their positions in the molecular structure [4–8]. The complex molecular structures of alcohol in liquid state are due to the formation of