1. Classify the type of mutation that have taken place: silent, missense and nonsense as a result of a single base substitution from UCG codon which codes for cysteine: a) AGC (ser): ________ b) UGU (cys): ________ c) GGC (gly): _______ d) UGA (stop): _______ e) UUC (phen): _______
1. Classify the type of mutation that have taken place: silent, missense and nonsense as a result of a single base substitution from UCG codon which codes for cysteine:
a) AGC (ser): ________
b) UGU (cys): ________
c) GGC (gly): _______
d) UGA (stop): _______
e) UUC (phen): _______
2. A single base addition and a single base deletion approximately 15 bases apart in the mRNA specifying the protein lysozyme from the bacterial virus T4 caused a change in the protein from
its wil-type composition….lys-ser-pro-ser-leu-asn-ala-ala-lys…..to the mutant form lys-val-his-his-leu-met-ala-alalys.
a. Decipher the segment of mRNA for both the original protein and the double mutant.
b. Which base was added? Which was deleted?
3. Given is the 30 nucleotides in the human gene for hemoglobin (the oxygen-carrying protein in the red blood cells): 5’ TAC-CAC-GTG-GAC-TGA-GGA-CTC-CTC-TTC-AGA 3’
a. What is the complementary strand?
b. Deduce the mRNA in this coding region.
c. What is the amino acid sequence based on this mRNA?
d. A very important mutation in human hemoglobin occurs in this DNA sequence, where the T at
Trending now
This is a popular solution!
Step by step
Solved in 3 steps
