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1. Determine the isoelectric pH (pI) of the amino acids (a) Met, M, (b) Glu, E and (c) Lys, K. Show your solutions clearly and systematically. Draw the structures (showing the states of protonation) of each amino acid before and after consecutive ionizations. Indicate the pH (i.e., pKa) values at which these ionizations occur. Specify the pKa values you used for the calculation of pl. The pKa values of the amino acids' ionizable groups are listed in the table below. Table 23.2 The pk, Values of Amino Acids pK, a-COOH pKa a-NH3+ pK. side chain Amino acid Alanine 2.34 9.69 Arginine 2.17 9.04 12.48 Asparagine Aspartic acid Cysteine 2.02 8.84 | 2.09 9.82 3.86 1.92 10.46 8.35 Glutamic acid 2.19 9.67 4.25 Glutamine 2.17 9.13 Glycine 2.34 9.60 | Histidine 1.82 9.17 6.04 Isoleucine 2.36 9.68 Leucine 2.36 9.60 Lysine 2.18 8.95 10.79 Methionine 2.28 9.21 Phenylalanine 2.16 9.18 Proline 1.99 10.60 Serine 2.21 9.15 Threonine 2.63 9.10 Tryptophan 2.38 9.39 Tyrosine 2.20 9.11 10.07 Valine 2.32 9.62

1. Determine the isoelectric pH (pI) of the amino acids (a) Met, M, (b) Glu, E and (c) Lys, K. Show your solutions clearly and systematically. Draw the structures (showing the states of protonation) of each amino acid before and after consecutive ionizations. Indicate the pH (i.e., pKa) values at which these ionizations occur. Specify the pKa values you used for the calculation of pl. The pKa values of the amino acids' ionizable groups are listed in the table below. Table 23.2 The pk, Values of Amino Acids pK, a-COOH pKa a-NH3+ pK. side chain Amino acid Alanine 2.34 9.69 Arginine 2.17 9.04 12.48 Asparagine Aspartic acid Cysteine 2.02 8.84 | 2.09 9.82 3.86 1.92 10.46 8.35 Glutamic acid 2.19 9.67 4.25 Glutamine 2.17 9.13 Glycine 2.34 9.60 | Histidine 1.82 9.17 6.04 Isoleucine 2.36 9.68 Leucine 2.36 9.60 Lysine 2.18 8.95 10.79 Methionine 2.28 9.21 Phenylalanine 2.16 9.18 Proline 1.99 10.60 Serine 2.21 9.15 Threonine 2.63 9.10 Tryptophan 2.38 9.39 Tyrosine 2.20 9.11 10.07 Valine 2.32 9.62

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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1. Determine the isoelectric pH (pI) of the amino acids (a) Met, M, (b) Glu, E and (c) Lys, K. Show your solutions clearly and systematically. Draw the structures (showing the states of protonation) of each amino acid before and after consecutive ionizations. Indicate the pH (i.e., pKa) values at which these ionizations occur. Specify the pKa values you used for the calculation of pl. The pKa values of the amino acids' ionizable groups are listed in the table below. Table 23.2 The pK, Values of Amino Acids pKa a-COOH pKa a-NH3+ pKa side chain Amino acid Alanine 2.34 9.69 Arginine 2.17 9.04 12.48 Asparagine 2.02 8.84 - Aspartic acid 2.09 9.82 3.86 Cysteine 1.92 10.46 8.35 Glutamic acid 2.19 9.67 4.25 Glutamine 2.17 9.13 Glycine 2.34 9.60 Histidine 1.82 9.17 6.04 Isoleucine 2.36 9.68 Leucine 2.36 9.60 Lysine 2.18 8.95 10.79 Methionine 2.28 9.21 Phenylalanine 2.16 9.18 Proline 1.99 10.60 Serine 2.21 9.15 Threonine 2.63 9.10 Tryptophan 2.38 9.39 Tyrosine 2.20 9.11 10.07 Valine 2.32 9.62 |
Transcribed Image Text:1. Determine the isoelectric pH (pI) of the amino acids (a) Met, M, (b) Glu, E and (c) Lys, K. Show your solutions clearly and systematically. Draw the structures (showing the states of protonation) of each amino acid before and after consecutive ionizations. Indicate the pH (i.e., pKa) values at which these ionizations occur. Specify the pKa values you used for the calculation of pl. The pKa values of the amino acids' ionizable groups are listed in the table below. Table 23.2 The pK, Values of Amino Acids pKa a-COOH pKa a-NH3+ pKa side chain Amino acid Alanine 2.34 9.69 Arginine 2.17 9.04 12.48 Asparagine 2.02 8.84 - Aspartic acid 2.09 9.82 3.86 Cysteine 1.92 10.46 8.35 Glutamic acid 2.19 9.67 4.25 Glutamine 2.17 9.13 Glycine 2.34 9.60 Histidine 1.82 9.17 6.04 Isoleucine 2.36 9.68 Leucine 2.36 9.60 Lysine 2.18 8.95 10.79 Methionine 2.28 9.21 Phenylalanine 2.16 9.18 Proline 1.99 10.60 Serine 2.21 9.15 Threonine 2.63 9.10 Tryptophan 2.38 9.39 Tyrosine 2.20 9.11 10.07 Valine 2.32 9.62 |
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