1. why is the ribosome a good drug target? 2. Tetracyclines: a. Where do first generation tetracyclines bind? b. Which step in protein translation do they inhibit? C. Why was it necessary to come out with a third generation tetracycline, and how are they different?

1. why is the ribosome a good drug target? 2. Tetracyclines: a. Where do first generation tetracyclines bind? b. Which step in protein translation do they inhibit? C. Why was it necessary to come out with a third generation tetracycline, and how are they different?

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter15: Genes And Proteins

Section: Chapter Questions

Problem 3VCQ: Figure 15.16 Many antibiotics inhibit bacterial protein synthesis. For example, tetracycline blocks...

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Concept explainers

Genomics

Genes are responsible for transmitting the characters located on the chromosomes from one individual to another across the generations. Genetics is the study of different genes that are involved in different functions. Genetics is a branch of biology that studies genes, genetic diversity, and heredity in living organisms. The genetic system consists of genetic notations, which is a system of signs and symbols. Genotype refers to the organism's genetic composition, and phenotype refers to the observable property of the organism.

Question

5. Macrolides:
a. Which step in protein synthesis does this class of drugs inhibit?
b. Do you think this class of drugs would be more effective in blocking the synthesis
of small or large proteins? Why?
6. Antibiotic resistance is a constant problem. List three ways that bacteria can be resistant
to antibiotics.

1. why is the ribosome a good drug target?
2. Tetracyclines:
a. Where do first generation tetracyclines bind?
b. Which step in protein translation do they inhibit?
C. Why was it necessary to come out with a third generation tetracycline, and how
are they different?
3. What are three ways that 2-deoxystreptamine (2-DOS) aminoglycosides can inhibit
protein synthesis?
4. Chloramphenicol:
a. Where does this drug bind?
b. How does it inhibit protein synthesis?

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