Please solve this 2. Below is an image of the NADH cofactor, labeled A.(a) What role does this cofactor play, and draw a mechanism that connects the variousstates this molecule cycles between as part of its biological role.(b) In addition, four molecules resembling NADH are shown (labeled B-E). Which ofthese could fulfill the same role as NADH? Which of these would act as inhibitor?Explain your reasoning. BDH₂NANH₂NH₂сERNH₂

NADH is vital in to metabolism and especially to the reactions that occur during release of energy…

Answered: 2. Below is an image of the NADH…

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter19: The Tricarboxylic Acid Cycle

Section: Chapter Questions

Problem 5P: Understanding the Action of Fluoroacetate on the TCA Cycle In a tissue where the TCA cycle has been...

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The Krebs cycle converts ________ through a cycle of reactions. In the process, ATP, ________, and ________ are produced. acetyl CoA; FAD, NAD acetyl CoA; FADH2; NADH pyruvate; NAD; FADH2 pyruvate; oxygen; oxaloacetate
7. Why are electron carriers (NAD+/NADH and FAD/FADH2) so important in the process of cellular respiration? a) They deliver electrons to the ETC, which in turn sets up chemiosmosis, where most of the ATP is generated. b) They separate the electrons from the protons so that the protons can be moved out of the mitochondrion. c) NADH and FADH2 are major components of the ETC, so without them, there would be no ETC in the cell. d) The electrons that they carry are able to directly phosphorylate ADP in order to generate the bulk of ATP in the cell. e) They transport protons across the mitochondrial membrane.
1. How many NADH _____& ATP _____are produced from the beta oxidation of Lauric Acid? 2. How many FADH2 _____& ATP _____are produced from the beta oxidation of Lauric Acid?
1. Under anaerobic conditions where does the NAD⁺ necessary for the complete oxidation of glucose come from? a. oxidation of acetaldehyde b. reduction of pyruvate c. reduction of lactate d. oxidation of ethanol
1. A cell in an active catabolic steady state state needs to maintain A. a high cytosolic (ATP/ADP) and a high cytosolic (NADH/NAD+) ratio. B. a high cytosolic (ATP/ADP) and a low cytosolic (NADH/NAD+) ratio. C. a low cytosolic (ATP/ADP) and a low cytosolic (NADH/NAD+) ratio. D. a low cytosolic (ATP/ADP) and a high cytosolic (NADH/NAD+) ratio.
4. If lots of acetyl-CoA is being formed in the mitochondrial matrix, a particular compound will be exported into the cytosol. a.What compound is this? b. What effect does this compound have on fatty acid synthesis? c. How does the compound produce this effect?
4) a)Fill in the blanks: When oxygen is the final energy carrier in the production of ATP, the process is called _________________. When an inorganic molecule is used to drive theoxidation in a cell to produce ATP, the process is called _______________.b)How is energy transferred to proteins in the process called phosphorylation?c) Fill in the blanks: When a molecule is oxidized it has (more/less) _________ electrons than it did before being oxidized. When a molecule is reducedit has (more/less)_________ electrons than it did before being reduced.d) Is NADH is the oxidized or reduced form of NAD+?
1) How is the TCA cycle regulated? a) Draw the TCA diagram that fills in all possible regulation points.
1 what is the common intermediary in the catabolism of carbohydrates, proteins and lipids? 2 What cyclic pathway doe sthis common metabolite enter? 3 what are the roles of NAD+ and FAD in metabolism 4 what are the reduced forms of NAD+ and FAD? 5 what are the entry point for the reduced forms of NAD+ and FAD in the electron transport chain?
5. a) The cell creates molecules of NADH and FADH2to use in the electron transport chain as they are electron carrier molecules. The electron transfers from these moleculesdrives the movement of what molecule across the mitochondrial membrane?b) What is chemiosmosis?c) How does the cell use chemiosmosis to drive overcome the thermodynamic barrier of bringing phosphates close togehter to create ATP?d) What steps of oxidative phosphorylation are in the cytosol and which are in the mitochondria?e) Cellular respiration can be controlled at the post-translational level. What does this mean, using GLUT as an example? Why is post-translational control of GLUT evolutionarilyadaptive over transcriptional control?f) How does establishment of equillibria of various molecules control metabolic reactions? What are three ways high ATP in the cell control cellular respiration?g) Why are the enzymes controlling the initial steps of various biochemical pathways are targeted by allosteric control?
When glucose reacts with ATP to form glucose-6-phosphate: a. the synthesis of glucose-6-phosphate is exergonic. b. ADP is at a higher energy level than ATP. c. glucose-6-phosphate is at a higher energy level than glucose. d. because ATP donates a phosphate to glucose, this is not a coupled reaction. e. the reaction is spontaneous.
Understanding the Action of Fluoroacetate on the TCA Cycle In a tissue where the TCA cycle has been inhibited by fluoroacetate, what difference in the concentration of each TCA cycle metabolite would you expect, compared with a normal, uninhibited tissue?

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