Please answer fast 26. Dietary triglycerides are hydrolyzed by pancreatic lipase, which is related to but distinct from lipase thatfunctions in adipose tissue. Would you expect pancreatic lipase to be activated by glucagon? Why orwhy not?27. Pancreatic lipase is structurally similar to the protease chymotrypsin, and shares the same catalytic triad(asp-his-ser). Below is a diagram of the active site of pancreatic lipase with a triglyceride bound. DrawA) Draw arrows on this diagram to show the mechanism for the formation of the acyl intermediateB) Draw the acyl intermediate in the right hand boxC) Draw arrows on the acyl intermediate to show the mechanism of its hydrolysisD) What type of catalysis is being played by the serine? By the histidine? What is the role of Phe77 andLeui53?Asp176RHis263Ser152.RRPhe7"RLeu153

The pancreas is a heterocrine gland because it secretes digestive juices and hormones. Pancreatic…

26. Dietary triglycerides are hydrolyzed by pancreatic lipase, which is related to but distinct from lipase that functions in adipose tissue. Would you expect pancreatic lipase to be activated by glucagon? Why or why not?

26. Dietary triglycerides are hydrolyzed by pancreatic lipase, which is related to but distinct from lipase that functions in adipose tissue. Would you expect pancreatic lipase to be activated by glucagon? Why or why not?

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter25: Nitrogen Acquisition And Amino Acid Metabolism

Section: Chapter Questions

Problem 16P: A Deficiency on 3-Phosphogtycerate Dehydrogenase Can Affect Amino Acid Metabolism Although serine is...

See similar textbooks

Related questions

Q: Describe the progression of this meal through the digestive system beginning in the mouth and ending...

A: Ingestion Food processing begins with ingestion (eating). The teeth aid in mechanical digestion by...

Q: Messenger RNA (MRNA) can be best described as: * A Chromosome that is only present in prokaryotes an...

A: Messenger RNA or mRNA are single stranded RNA molecules that carries genetic information from the DN...

Q: How many different chemical units make up a nucleoside? (А) 5 в) 2 c) 4 D) 3

A: We are authorized to answer one question at a time, since you have not mentioned which question you ...

Q: Glucose Pyruvate r Pyrovate ATP What stage of cellular respiration is this? Explain the purpose and ...

A: Glucose converts to two molecules of pyruvate.

Q: Deoxyribonucleotides a) Lack a hydroxyl group at position 2 of the sugar molecule b) Lack a hydrox...

A: Nucleotides are composed of nitrogenous base, a pentose sugar and a phosphate. DNA contains deoxyrib...

Q: 3. Tumor derived growth factor B (TGFB) is a secreted protein that has a diverse range of blological...

A: TGF-β (Transforming Growth Factor-β) employs the Smad proteins as the intracellular mediator of sign...

Q: Each of the following statements concerning mitochondria is true, EXCEPT a.The mitochondria require...

Q: A protein-ligand binding reaction is run. At equilibrium, half the protein is ligand bound, the unbo...

A: The receptor-ligand interaction involves the binding of the ligand on the active site of the recepto...

Q: Identify the amino acids present in the structure from N terminal to C terminal. (answer in lower ca...

A: Amino acids are building blocks of proteins, It is organic molecule and compose of carbon, hydrogen,...

Q: Carbons is used in cells for a) forming the charge across the membrane by serving a positive catio...

A: Cell mass - Composed of elements present in nature out of which carbon is a very important element.

Q: Shown here is a monosachharide. How many biological forms of this sugar are there? 1CHO 2 HO- 3 H OH...

Q: POST-LAB QUESTIONS: A. Molisch Test 1. Describe the evidence for a positive test. 2. What does a pos...

A: The Molisch test is a qualitative analysis for the confirmation of the presence of carbohydrates in ...

Q: How many different components make up a nucleoside? 4 2 3 5

A: Nucleosides are glycosylamines that are phosphorylated to form nucleotides.

Q: Which of the following structures is a 20:2 ^A4,9 fatty acid? CH3CH2CH = CH(CH2)3CH = CH(CH2)10COOH ...

A: given fatty acid is 20:2^△4,9. Number of carbon in fatty acid = 20 Number of double bond = 2 Number...

Q: The ionizable side change (-OH) of a synthetic amino acid has a pKa of 6.54. Find the amino acid's i...

A: The pH at which the amino acid has no net charge and is electrically neutral is called isoelectric p...

Q: An enzyme E binds a substrate S and a cofactor C. The equilibrium dissociation constant Kd,S of the ...

A: Enzymes are usually made of protein molecules which increase the rate of biochemical reaction by dec...

Q: [N] NO MATCH 1. yields 2 moles of fatty acid, phosphoric acid, glycerol and choline upon hydrolysis ...

A: Since we only answer up to 3 sub-parts, we'll answer the first 3. Please resubmit the question and s...

Q: Amino acids are joined together into a protein chain by which of the following? * DNA polymerase hyd...

A: Proteins are essential molecules in the living system. All the physiological and cellular processes ...

Q: Test Added reagent/s Samples Observation and interpretation lodine Test Glucose Lactose Sucrose Star...

A: Iodine test is used for the determination of starch in a solution. Starch forms a deep-blue color wh...

Q: 2.) An unknown amino acid was subjected to paper chromatography with five amino acid standards in or...

A: For Thin layer chromatography, we define Retension factor (Rf) as ratio of distance travelled by sol...

Q: Draw the Micelle generated when the soap is dissolved in water and the heater. For this representati...

Q: Explain why sucrose is non reducing sugar

A: The carbohydrates that are capable of causing the reduction of other substances without being hydrol...

Q: The translated peptide chain is: Asn-Ser-Arg-GIn. What is the name of the UCAGUCAGUGFOSGTO protein? ...

A: Amino acid - Coded by codon (having 3 Nitrogenous Bases) Asn - Asparagine Ser - Serine Arg - Arginin...

Q: Directions: Complete the table below to summarize your understanding of the structures, properties, ...

A: Biomolecules are carbon-based organic compounds that are produced in living organisms. Biomolecules ...

Q: . Relationship of Drug solubility & dissolution rate on Physico-Chemical Properties 2. Relationshi...

A: 1.Physicochemical properties: The ability of a chemical compound to elicit a pharmacological/ therap...

Q: structure of cysteine at pH 8.2 and what is its charge?

A: Cysteine is a sulfur-containing amino acid. It is an amino acid with an uncharged polar side chain a...

Q: Give the name of the triglyceride. * H. C-0 H-C-0 H-C-O エー0ーエ I-o-I I-ó-z エー0ーエ HIC-エ HICIH エーローエ HI...

A: Given name of the Triglyceride: The given Triglyceride structure is basically having 3 saturated cha...

Q: what molecule is responsible for protein synthesis *

A: Proteins are polymers of amino acids, linked by amide/peptide bond with release of a water molecule....

Q: In moelcular genetics, initiation is often accomplished using proteins that prevent elongation. Nam...

A: Initiation of a process in genetics is an important event. At this stage, cell prepare itself for th...

Q: Which of the following is a carbohydrate with 6 carbon atoms and a keto group as functional group? *...

A: Ketose and aldose are monosaccharides which can be differentiated based on the carbonyl group. An al...

Q: 10 samples of genetically modified organisms ( Animals ) With brief descriptions of each

A: Genetically modified organisms (GMOs) are those organisms (plants, animals or microorganisms) whose ...

Q: ENDOSYMBIOTIC THEORY application to this subject (BIOMOLECULES)?

A: Endosymbiosis is one of many different types of symbiotic connections (symbioses) that can exist bet...

Q: I. Name the following carbohydrates using the proper way of naming/IUPAC system. a. Erythrose b. Lyx...

A: Since there are 3 questions asked, we will solve the first question. If you need the solutions of th...

Q: What is the importance of culture media in the diagnosis of plant disease?

A: Plant disease: A disease is defined as any type of injurious abnormality and it is the pathogen tha...

Q: How much of world food production is lost to diseases every year? What areas of the world suffers th...

A: Plants and animals are among the two major legs of agricultural practices. Agriculture is important ...

Q: I. Name the following carbohydrates using the proper way of naming/IUPAC system. a. Erythrose b. Lyx...

A: Carbohydrates are the primary source of energy for the body. Glucose is the simplest form of carbohy...

Q: The structure of an amino acid at pH 7 is shown below. This amino acid is most likely СОО- H-C-CH3 N...

A: Amino acids remain as zwitterions, which is a dipolar ion that occurs as a result of an internal aci...

Q: Which of the following is not a top category for enzymes according to the International Classificati...

A: The human body consists of a huge network of various cells, tissues, organs, and glands. All of them...

Q: Which of the following is correct regarding nucleotide structure? Removal of the ribose-phosphate...

A: A nucleotides are the basic building blocks of nucleic acids (RNA or DNA).

Q: POST-LAB QUESTIONS E. Seliwanoff's Test 1. Describe the evidence for a positive test. 2. What does a...

A: Most of the carbohydrates can be distinguished from each other based on the condensation reaction us...

Q: 1) Describe what happens to a cell in a hypertonic solution. 2) Describe what happens to a cell in a...

A: 1) When the cell is put in hypertonic solution, the concentration of solutes in the solution is grea...

Q: If you have a protein kinase that is regulated by both small molecule inhibitors as well as by phosp...

A: Protein kinases is enzyme which catalyses the transfer of phosphate between their substrates. A prot...

Q: The enzymes that are involved in regulation and control of pathways are. . *

A: Enzymes are highly specialized proteins that have extraordinary catalytic power, greater than that ...

Q: Match the structures a mixed triglyceride a mineralocorticoid steroid hormone a weakly amphipathic...

A: Mixed triglycerides are molecules in which the the three –OH groups of the glycerol are esterified w...

Q: Which of the following is cytidine? cytosine + guanine ribose + cytosine + phosphate group ...

A: Cytidine is a nucleoside monomer formed when a cytosine gets attached to a ribose sugar via a glycos...

Q: movement of water into the hypertonic solution. If a cell is hypotonic relative to its environment, ...

A: Biological transport of solute and solvents often occurs via semipermeable membranes. Such a mode of...

Q: a. Identify the regulatory process an%3; b. Explain how this process works

A: Enzymes are biocatalyst. They act on a substrate and product is formed. Enzymes increases the speed...

Q: Propose one amino acid substitution that would disrupt the leucine zipper structure and explain why

A: Leucine zipper structure is formed by leucine residues and these leucine residues are held together ...

Q: The carbonic acid equilibrium is shown below. Exhalation of CO2 by the lungs causes this equilibrium...

A: Equilibrium shifts to the side where the concentration of substance is lowered so as to produce more...

Q: Give the drug examples of emulsion prepare by these method:- 1)dry gum method 2)wet gum method 3)bot...

A: Emulsions are heterogeneous biphasic systems. Thus, there are two immiscible phases. One of the syst...

Question

Please answer fast

26. Dietary triglycerides are hydrolyzed by pancreatic lipase, which is related to but distinct from lipase that
functions in adipose tissue. Would you expect pancreatic lipase to be activated by glucagon? Why or
why not?
27. Pancreatic lipase is structurally similar to the protease chymotrypsin, and shares the same catalytic triad
(asp-his-ser). Below is a diagram of the active site of pancreatic lipase with a triglyceride bound. Draw
A) Draw arrows on this diagram to show the mechanism for the formation of the acyl intermediate
B) Draw the acyl intermediate in the right hand box
C) Draw arrows on the acyl intermediate to show the mechanism of its hydrolysis
D) What type of catalysis is being played by the serine? By the histidine? What is the role of Phe77 and
Leui53?
Asp176
R
His263
Ser152
.R
R
Phe7"
R
Leu153

Expert Solution

This question has been solved!

Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.

This is a popular solution!

SEE SOLUTION Check out a sample Q&A here

Step 1

VIEW

Step 2

VIEW

Step 3

VIEW

Trending now

This is a popular solution!

Step by step

Solved in 3 steps

SEE SOLUTION Check out a sample Q&A here

Similar questions

A Deficiency on 3-Phosphogtycerate Dehydrogenase Can Affect Amino Acid Metabolism Although serine is a nonessential amino acid, serine deficiency syndrome has been observed in humans. One such form of the syndrome is traceable to a deficiency in 3-phosphoglycerate dehydrogenase (see Figure 25.31). Individuals with this syndrome not only arc serine-deficient but also arc impaired in their ability to synthesize another common ammo acid, as well as a class of lipids. Describe why.
If phenylalanine was not an essential amino acid, would diet therapy (the elimination of phenylalanine from the diet) for PKU work?
Radiolabeling with 14C-Glutamate Describe the labeling pattern that would result from the introduction into the TCA cycle of glutamate labeled at Cy with 14C.
Although animals cannot synthesize glucose from acetyl-CoA, if a rat is fed 14C-labeled acetate, some of the label appears in glycogen extracted from its muscles. Explain.
If glucagon binds to the liver cell, what is the expected regulation of the bifunctional enzyme phosphofructokinase-2/fructose-2,6-bisphosphatase and how would the levels of fructose-2,6-bisphosphate be impacted?
Define beta-oxidation of fatty acids? Describe in detail three different steps of beta-oxidation of FAs.
1. Discuss fully the synthesis of triacylglycerol in the adipose tissue, muscles, intestines and liver. 2. Describe adequately the beta-oxidation of fatty acids. 3. Discuss the synthesis and utilization of ketone bodies.
Only carbon skeleton of amino acids are used in glucogeneogenesis but not fatty acids. How can fatty acid oxidation in the liver then provide fuel for the brain ? Explain the pathways and compounds involved
Figure 22.3 6 shows the response of acetyl CoA carboxylase to varying amounts of citrate. Explain this effect in light of the allosteric effects that citrate has on the enzyme. Predict the effects of increasing concentrations of palmitoyl CoA.
Consider the each of the amino acids in the peptide below. Ala-Ile-Asp-Arg-Gln-Gly-Pro-Gly-Ala-Tyr-Val-Ile-Gln-Leu If all of the amino acids are degraded to yield energy (ATP), explain how many Acetyl CoAs for oxidation to CO2 could be produced from this peptide. note: Do not make glucose at the beginning, however converting the TCA intermediates into molecules in the glycolytic pathway for optimal Acetyl CoA production is allowed. Be sure to show clearly which pathway will the Acetyl CoA enter (to yield ATP ultimately) under such condition
Starting with acetyl-S-enzyme-1 and malonyl-CoA, how many molecules of acetyl- CoA are needed to synthesize an 18-carbon fatty acid (C18:0)? How many molecules of CO2 are released in this process?
Order the steps that results in a triacylglycerol containing two palmitic acids and one stearic acid. a. Diacylglycerol reacts with an fatty-acyl-CoA b. Phosphate is remove from phosphatidic acid to form diacylglycerol c. Two of the fatty acyl-CoAs react with glycerol-3-phosphate d. An elongase produce stearic acid e. Stearoyl-CoA is synthesized…