30. At what pH would you expect the aminoacid proline (P) to be fully protonated? pK₁ = 1.952, pK2 = 10.640. A. 1.952 B. 1.750 C. 2.500 D. 10.640 E. 7.000 31. Given pką values of citric acid (2-hydroxypropane-1,2,3-tricarboxylic acid), pK₁ = 3.128, pK₂ = 4.761, and pK3 = 6.396, calculate the first base association constant for sodium citrate. A. 7.45 x 10-4 B. 1.73 x 10-5 C. 2.49 x 10-8 D. 4.02 x 10-7 E. 1.34 x 10-11 32. The aminoacid tyrosine (Y) has three acidic protons in fully protonated form: H3Y+ (pK1 = 2.17)→ H₂Y (pK2=9.19)→ HY (pK3 = 10.47)→ Y2-. Calculate the pH of 0.0150 M tyrosine. A. 2.17 B. 5.68 C. 6.34 D. 1.82 E. 10.47

30. At what pH would you expect the aminoacid proline (P) to be fully protonated? pK₁ = 1.952, pK2 = 10.640. A. 1.952 B. 1.750 C. 2.500 D. 10.640 E. 7.000 31. Given pką values of citric acid (2-hydroxypropane-1,2,3-tricarboxylic acid), pK₁ = 3.128, pK₂ = 4.761, and pK3 = 6.396, calculate the first base association constant for sodium citrate. A. 7.45 x 10-4 B. 1.73 x 10-5 C. 2.49 x 10-8 D. 4.02 x 10-7 E. 1.34 x 10-11 32. The aminoacid tyrosine (Y) has three acidic protons in fully protonated form: H3Y+ (pK1 = 2.17)→ H₂Y (pK2=9.19)→ HY (pK3 = 10.47)→ Y2-. Calculate the pH of 0.0150 M tyrosine. A. 2.17 B. 5.68 C. 6.34 D. 1.82 E. 10.47

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter27: Amino Acids And Proteins

Section: Chapter Questions

Problem 27.39P: A chemically modified guanidino group is present in cimetidine (Tagamet), a widely prescribed drug...

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A chemically modified guanidino group is present in cimetidine (Tagamet), a widely prescribed drug for the control of gastric acidity and peptic ulcers. Cimetidine reduces gastric acid secretion by inhibiting the interaction of histamine with gastric H2 receptors. In the development of this drug, a cyano group was added to the substituted guanidino group to alter its basicity. Do you expect this modified guanidino group to be more basic or less basic than the guanidino group of arginine? Explain.
For the amino acid glutamate, what fraction of the side-chain (R-group) will be ionized at pH = 3.5? At pH = 5.0?
For the amino acid alanine, the major species in solution at pH 7 is the zwitterionic form, which has a negatively charged carboxylic acid group and a positively charged amino group. There is a less common neutral form in which neither group is charged. The carboxylic acid group of alanine has a p?apKa of 3.3. The amino group of alanine has a p?apKa of 8.8. Estimate the ratio of the concentration of the neutral amino acid species to the zwitterionic species at pH 7.
For the amino acid alanine, the major species in solution at pH 7 is the zwitterionic form, which has a negatively charged carboxylic acid group and a positively charged amino group. There is a less common neutral form in which neither group is charged. The carboxylic acid group of alanine has a p?a of 3 The amino group of alanine has a p?a of 8 Estimate the ratio of the concentration of the neutral amino acid species to the zwitterionic species at pH 7. __?__x10^?
Tyrosine is an amino acid whose side chain has a pKa of 10.1. At pH 7, what protonation form would you expect to find it in?
Consider the amino acid and its pKa values:Lysine: pKa1= 2.18 pKa2= 8.95, pKaR=10.79 a. Calculate the isoelectric point.b. What will be the net charge on lysine at the isoelectric point?c. In what direction will the lysine move when placed in an electric field at a pH value of 6.68d. Which form of the lysine is the least soluble in water?e. Draw the structure of the lysine which is the least soluble in water?
If the pH of a solution of Arginine is equal to a half of the 3 pka values of all of its functional groups, what will be the charge on the majority of the Arg molecules in that solution? Please explain. Am i supposedd to add up the three pka values and then divide it in half to find the pH? Thanks
There are two pH values in which Glutamic acid will have an a complete net charge of 2.17? what is the lowest PH1 and highest of pH2 round your amswers to the nearest 0.1 no orher information was provided
The initial pH of a 2M arginine solution is 14. What is the predominant structure of arginine in solution at this pH?
Glutamic acid is a naturally occurring α-amino acid that contains acarboxy group in its R group side chain. (Glutamic acid isdrawn in its neutral form with no charged atoms, a form that does not actually exist at any pH.) a.) What form of glutamic acid exists at pH = 1?b.) If the pH is gradually increased, what form of glutamic acid exists afterone equivalent of base is added? After two equivalents? After threeequivalents?c.) Propose a structure of monosodium glutamate, the common flavorenhancer known as MSG.
Almost all proteins are composed from a set of about _____ amino acids.a. 4b. 10c. 20d. 50 ______ amino acids are considered essential.a. 5b. 10c. 15d. 20 An amino acid that has an indole group side chain.a. Trpb. Phec. Tyrd. ProWhich of the following is the simplest amino acid?a. Alab. Glyc. Vald. ProWhich of these will not give a blue solution with Ninhydrin testa. Prob. Phec. Alad. CysA neutral molecule with a positive and negative electrical charge.a. Isoelectric pointb. Zwitterionsc. Bufferd. Amphoteric3 amino acids joined together by two peptide bonds.a. Dipeptideb. Tripeptidec. Tetrapeptided. PolypeptideAn amino acid that can form disulfide bondsa. Cysteineb. Methioninec. Cystined. SerineWhich of the following is not a property of amino acidsa. Bufferb. Isoelectric pointc. Zwitterionsd. Insoluble in waterThe protein primary structure is held together bya. Hydrogen bondsb. Disulfide bondsc. Peptide bondsd. Protein bonds
A compound is known to have a free amino group with a pKa of 8.6, and one other ionizible group with a pKa between 5 and 7. To 90mL of a 0.150M solution of this compound at pH 7.80 was added 35 mL of a solution of 0.18 M HCl. The pH changed to 6.40. What is the pKa of the second ionizable group?