5. The acyl group is a protecting group for amines which can be deprotected by treatment with sodium hydroxide. Please write mechanisms for both the protection and deprotection steps. NaOH 人人 CH30-H NH2 NH2 protect deprotect amine acetic anhydride N-acyl amine

5. The acyl group is a protecting group for amines which can be deprotected by treatment with sodium hydroxide. Please write mechanisms for both the protection and deprotection steps. NaOH 人人 CH30-H NH2 NH2 protect deprotect amine acetic anhydride N-acyl amine

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter24: Amines And Heterocycles

Section24.SE: Something Extra

Problem 37MP

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Concept explainers

Amines

Amines are organic compounds with a nitrogen atom having a lone pair of electrons on it. They are derived from ammonia (NH3) wherein hydrogen atoms are substituted by an aryl or alkyl group.

Question

5. The acyl group is a protecting group for amines which can be deprotected by
treatment with sodium hydroxide. Please write mechanisms for both the protection
and deprotection steps.
NaOH
CH30-H
NH2
protect
deprotect
R
NH2
amine
acetic anhydride
N-acyl amine

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