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A AnoH oud or-eros0WSE WnoiSoutOTO4I2II510837II103645IV16 7 858. If individuals IV-3 and IV-4 marry, what is the probability that their first child will have the disease?The answe is9. Statistically, this trait has a probability of 0.0001 in the population in which these families live. IfIV5 is married with a man who is also in this community. What is the probability if your first child hasthis trait?E. 0.246%D. 0.123%C. 0.165%B.0.0413%A. 0.0825%10. If the disease is inherited as an autosomal dominant trait with 50 % penetrance, then what would bethe possibility that the first child from the marriage of IV3 and IV4 shows this disease?A 1.0D. 0.1342E. None of theC. 0.0313B. 0.0417answers.M

Question

Hello! Please help me with question 10!

A A
noH oud or-eros
0WSE W
noi
Sout
OTO
4
I
2
II
5
10
8
3
7
II
10
3
6
4
5
IV
1
6 7 8
5
8. If individuals IV-3 and IV-4 marry, what is the probability that their first child will have the disease?
The answe is
9. Statistically, this trait has a probability of 0.0001 in the population in which these families live. If
IV5 is married with a man who is also in this community. What is the probability if your first child has
this trait?
E. 0.246%
D. 0.123%
C. 0.165%
B.0.0413%
A. 0.0825%
10. If the disease is inherited as an autosomal dominant trait with 50 % penetrance, then what would be
the possibility that the first child from the marriage of IV3 and IV4 shows this disease?
A 1.0
D. 0.1342
E. None of the
C. 0.0313
B. 0.0417
answers.
M
help_outline

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A A noH oud or-eros 0WSE W noi Sout OTO 4 I 2 II 5 10 8 3 7 II 10 3 6 4 5 IV 1 6 7 8 5 8. If individuals IV-3 and IV-4 marry, what is the probability that their first child will have the disease? The answe is 9. Statistically, this trait has a probability of 0.0001 in the population in which these families live. If IV5 is married with a man who is also in this community. What is the probability if your first child has this trait? E. 0.246% D. 0.123% C. 0.165% B.0.0413% A. 0.0825% 10. If the disease is inherited as an autosomal dominant trait with 50 % penetrance, then what would be the possibility that the first child from the marriage of IV3 and IV4 shows this disease? A 1.0 D. 0.1342 E. None of the C. 0.0313 B. 0.0417 answers. M

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Step 1

If a trait or disorder is autosomal dominant in nature, then it must pass on to the next generation. Moreover, one of the parents must also be affected by the trait. Only one gene of this trait is enough to be expressed in the individual. Moreover, autosomal traits are independent of the sex of the individual.

Step 2

In genetics, penetrance is the proportion of the individuals who carry a certain gene and also expresses the same gene. In the given pedigree analysis, the autosomal dominant trait shows 50 percent penetrance. This means out of all the...

The probability of the individual in 5th generation to have disease = (penetrance)
n number of generations
hence
The probability of the individual in 5th generation to have disease = (50%)
2
1
32
=0.0312
-
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The probability of the individual in 5th generation to have disease = (penetrance) n number of generations hence The probability of the individual in 5th generation to have disease = (50%) 2 1 32 =0.0312 -

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