A small-scale pedigree study involving 15 families with a total of 50 children was performed to determine whether a SNP in a candidate gene is linked to a disease. The result showed that among 22 children who developed the disease, 19 belonged to non-recombinants while 3 recombinants. For the remaining 28 children, 21 were non-recombinants and 7 belonged to recombinants. A Lod (Z) score can be calculated and used to determine whether this SNP is linked to the disease. By using a very stringent threshold, which of the following conclusions is correct? OA.Z is approximately 4.03, indicating a linkage O B. Z=0.25, indicating no linkage OC.Z=0.2, indicating no linkage O D.Z is approximately 4.19, indicating a linkage

A small-scale pedigree study involving 15 families with a total of 50 children was performed to determine whether a SNP in a candidate gene is linked to a disease. The result showed that among 22 children who developed the disease, 19 belonged to non-recombinants while 3 recombinants. For the remaining 28 children, 21 were non-recombinants and 7 belonged to recombinants. A Lod (Z) score can be calculated and used to determine whether this SNP is linked to the disease. By using a very stringent threshold, which of the following conclusions is correct? OA.Z is approximately 4.03, indicating a linkage O B. Z=0.25, indicating no linkage OC.Z=0.2, indicating no linkage O D.Z is approximately 4.19, indicating a linkage

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Description: A small-scale pedigree study involving 15 families with a total of 50 children was performed to determine whether a SNPin a candidate gene is linked to a disease. The result showed that among 22 children who developed the disease, 19belonged to non-

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter4: Pedigree Analysis In Human Genetics

Section: Chapter Questions

Problem 10QP: A proband female with an unidentified disease seeks the advice of a genetic counselor before...

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