At least three hemoglobin alleles in human populations alterhemoglobin structure in such a way as to impair the transportof O2 by the blood but enhance resistance of red blood cells toparasitization by malaria parasites. Explain how such allelesexemplify pleiotropy, and discuss whether such alleles couldlead to nonadaptive evolution of blood O2 transport in certainsituations.

Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
Publisher:Michael Cummings
Chapter19: Population Genetics And Human Evolution
Section: Chapter Questions
Problem 2CS: If allele frequencies in the hemoglobin gene are influenced by sickle cell anemia on the one hand...
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At least three hemoglobin alleles in human populations alter
hemoglobin structure in such a way as to impair the transport
of O2 by the blood but enhance resistance of red blood cells to
parasitization by malaria parasites. Explain how such alleles
exemplify pleiotropy, and discuss whether such alleles could
lead to nonadaptive evolution of blood O2 transport in certain
situations.

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