A woman has her personal genome analyzed for the BRCA1 mutation after learning that her father is heterozygous and carries one mutant allele. What is her chance of inheriting the mutant allele from her father? 0: men cannot transmit genes affecting breast cancer. 25% 50% 75% 100% Among the progeny of a heterozygous round (Aa) x homozygous wrinkled (aa) cross, three seeds are chosen at random What is the probability that all three seeds are round? (1/4)3 1/4 (1/2)3 1/2 A single gene can produce different proteins. True False

A woman has her personal genome analyzed for the BRCA1 mutation after learning that her father is heterozygous and carries one mutant allele. What is her chance of inheriting the mutant allele from her father? 0: men cannot transmit genes affecting breast cancer. 25% 50% 75% 100% Among the progeny of a heterozygous round (Aa) x homozygous wrinkled (aa) cross, three seeds are chosen at random What is the probability that all three seeds are round? (1/4)3 1/4 (1/2)3 1/2 A single gene can produce different proteins. True False

Name: A woman has her personal genome analyzed for the BRCA1 mutation after
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Description: A woman has her personal genome analyzed for the BRCA1 mutation after learning that her father is heterozygous and carries one mutant allele. What is her chance ofinheriting the mutant allele from her father?0: men cannot transmit genes affecting br

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter4: Pedigree Analysis In Human Genetics

Section: Chapter Questions

Problem 10QP: A proband female with an unidentified disease seeks the advice of a genetic counselor before...

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In a particular country in sub-Saharan Africa, a medical study revealed that 0.075% of the country's population are suffering from sickle-cell anemia. Sickle cell disease is caused by a mutation in the haemoglobin-Beta gene found on chromosome 11. Sickle cell anemia is controlled by a pair of alleles, H and h, where the individuals with the illness have the homozygous recessive genotype; those with normal red blood cells have the alternative genotype. Using the Hardy-Weinberg's equation, calculate the percentage of the population of the two genotypes for normal blood cells. In a few remote areas in that country, the percentage of sickle cell anemia reaches as high as 5%. Calculate the percentage of homozygous and heterozygous individuals with the normal blood cells and find the ratio for both phenotypes.
DNA sequencing of your own two β-globin genes (one from each of your two Chromosome 11s) reveals a mutation in one of the genes. given this information alone, should you worry about being a carrier of an inherited disease that could be passed on to your children? What other information would you like to have to assess your risk?
A genetic disorder is caused by a LOF mutation (Bm) and epigenetic imprinting of gene B. Through pedigree analysis of many families, researchers have observed the following results: Female carrier B+Bm x B+B+ --> B+Bm and Mother's genotype Father's genotype Children's genotype Children's phenotype Cross 1: B+Bm B+B+ B+Bm , B+B+ some affected, some unaffected Cross 2: B+B+ B+Bm B+Bm , B+B+ always unaffected Based on these results, gene B is imprinted on the: a. maternal b. paternal
What the grandparents' genotypes are? Why doesn’t the father (II-1) have the disease breast cancer? What is the formal name for an individual having the gene but not showing the trait? For this particular family, what is the recombination rate between the D17S74 marker and the breast cancer gene?
In a certain family with both parents affected with Heberdon’s nodes, a single gene trait characterized by enlargement of the terminal joints of the fingers, there were 8 children: 4 boys, all affected and 4 girls, two of whom express the trait. One of the normal daughters married a normal man. They had five children, three normal girls and two boys, one with affliction. One of the affected daughters married a normal man and had six children, four affected boys and two normal girls. Construct a pedigree Give the mode of inheritance of this trait Provide all the genotypes of all individuals in your pedigree based on your mode of inheritance
For this particular family, what is the recombination rate between the D17S74 marker and the breast cancer gene? Lets say that at age 45 the third granddaughter III-3, is diagnosed with breast cancer. Now recalculate the recombination rate between the marker locus D17S74 and the breast cancer gene? Use only the 5 women in your analysis:the two daugthers in generation II and the three granddaughters in generation II
You are a gene hunter, trying to find the genetic basis for a rare inherited disease. Examination of six pedigrees of families affected by the disease provides inconsistent results. For two of the families, the disease is co-inherited with markers on chromosome 7. For the other four families, the disease is co-inherited with markers on chromosome 12. Explain how this difference might have arisen.
A RFLP is discovered that is linked to the gene for Duchenne’s muscular dystrophy (DMD). DMD is an X-linked, recessive trait. The RFLP is 2 map units from the gene for DMD. Consider the following pedigree and Southern blot using a probe that hybridizes to the RFLP. Which band/s is/are associated with DMD? What is the genotype for individuals 3 and 4? (Remember, this is an X linked disease, so use X’s and Y’s to denote). Individual 9 married a man who does NOT have muscular dystrophy, and she is pregnant. DMD is an X-linked trait. What is the probability for their child to have DMD? An amniocentesis is performed and it is determined that 9’s child in utero has only a 10 kb band that hybridizes to the same probe used above. What can you say about the child now?
The pedigree below is of a rare single gene disease. Given the pedigree shown below, what is the most likely pattern of inheritance for this disease? Explain your answer. Note that closed symbols are for individuals affected by the disease and open symbols are unaffected individuals (limit 3-4 sentences).
Marfan syndrome is a disease caused by a rare dominant allele of the fibrillin-1 gene. Fibrillin-1 is an important component of the extracellular matrix, and people with the disease-causing allele have abnormal connective tissue. An affected mother (Marta) and an unaffected father (Joe) have one unaffected daughter (Luisa - she does not exhibit any traits of the syndrome). If Luisa has a child with Nico (unaffected), what is the probability that her child will inherit Marfan syndrome? Select one: a. 50% b. 25% c. 100% d. 0% e. 75%
Six months pregnant, an expectant mother had a routine ultrasound that showed that the limbs of the fetus were unusually short. Her physician suspected that the baby might have a genetic form of dwarfism called achondroplasia, an autosomal dominant trait occurring with a frequency of about 1 in 27,000 births. The parents were directed to a genetic counselor to discuss this diagnosis. In the conference, they learned that achondroplasia is caused by a mutant allele. Sometimes it is passed from one generation to another, but in 80 percent of all cases it is the result of a spontaneous mutation that arises in a gamete of one of the parents. They also learned that most children with achondroplasia have normal intelligence and a normal life span. 1. What information would be most relevant to concluding which of the two mutation origins, inherited or new, most likely pertains in this case? How does this conclusion impact on this couple’s decision to have more children? 2. It has been…
Red-green color blindness is inherited as an X-linked recessive (Xc). If a color-blind man marries a woman who is heterozygous for normal vision, what would be the expected phenotypes of their children with reference to this character? In your answer, specify in your phenotype descriptions the gender of the children. (For example, don’t just say 75% of the children would be colorblind – you would instead say 100 % of the daughters would be colorblind and 50% of the sons would be colorblind. Note that this is not a correct answer; it is just to give you an idea of how to explain the correct phenotypes of the cross.)___