An enzyme binding equilibrilum has a Kd = 50 mM. What concentrationof ligand (in mM) is required in order to bind 10% of the enzyme?

In the given question we have to calculate the concentration of ligand which is required to bind 10%…

Answered: An enzyme binding equilibrium has a Ka…

An enzyme binding equilibrium has a Ka = 50 mM. What concentration of ligand (in mM) is required in order to bind 10% of the enzyme? %3D

Appl Of Ms Excel In Analytical Chemistry

2nd Edition

ISBN:9781285686691

Author:Crouch

Publisher:Crouch

Chapter11: Dynamic Electrochemistry

Section: Chapter Questions

Problem 8P

See similar textbooks

Related questions

Q: For which member of the following pairs of complexes would ΔO be larger and why? i. [Cr(H2O)6]2+ and…

A: Since we only answer up to 3 sub-parts, we’ll answer the first 3. Please resubmit the question and…

Q: Examine the image of a graph of fraction bound versus ligand concentration. The protein in question…

A: As per bartleby guidelines, an expert is allowed to answer ONE question at a time. Please reupload…

Q: Is my work correct? Question: What is the percent yeild of the nicke(II) coordination?…

A: The number of moles for a given chemical species refers to the ratio of mass of the species to that…

Q: Q1 a) Name the following complexes: KĄ[PtBr], Fe[Fe(CN)6], [Cr(en);]Cl3 b) Draw the complex…

A: a) K4[ptcl6] : potassium hexachloridoplatinate(II) Fe[FeCN6] : Iron(III) Hexacyanidoferrate(III)…

Q: What is the formula of the coordination compound containing anion [Fe(OH)6]3- and cation Na+ ? a.…

A: Anion = [Fe(OH)6]3- Cation = Na+ To write the formula of coordination compound: Step 1. Write the…

Q: The equilibrium constant of the reaction in aqueous solution is K = 5.00.…

A: The reaction given is, => CH3Hg(glutathione)+ (aq) + Cysteine (aq) → CH3HG(cysteine)+ (aq) +…

Q: Find the correct name for the complex [Fe(CN)5(H2O)]²-: aquapentacyanidoferrate(III) a b b.…

A: Complex compounds are also known as coordination compounds. These compounds can retain their…

Q: Use the trans directing effect of ligands to suggest the reaction pathways to synthesize the isomers…

A: the trans effect is the labilization of ligands that are trans to certain other ligands, which can…

Q: An aqueous complex absorbs strongly at 528 nm. What color does the solution appear? 650 nm 580 nm R…

A: Given that, Absorb wavelength = 528 nm

Q: A protein has a binding affinity for its lignd of Ka =2 x 10^5M at pH 7.0 and 25 degrees celcius. At…

A: The concentration of ligand at which half of the protein will be bound can be calculated using the…

Q: Which is the correct name for the complex [Co(NH3)6 ? O a. hexaamminecobaltate(II) ion O b.…

Q: dissociation constant, Kd, for a particular repressor-operator complex is approximately 10-¹1 M. The…

A: Dear student I am allowed to answer only 1 question so please post the other separately. I will…

Q: The order of stabilities of metal porphyrin complexes is Pt(II) > Pd(II) > Ni(II) > Co(II) > Cu(ll)…

A: The answer is explained in the image provided below.

Q: Write the formula of the original (six-coordinate) coordination compound and name it (please show…

A: The compound in which the metal atom is surrounded by the ligands is known as coordination compound.…

Q: At 510 nm, the iron orthophenanthroline complex has a molar absorptivity of 1.2 x 104. What is the…

A: The concentration of irom complex can be determined by using Beer-Lambar law which is expressed…

Q: Which is the correct name for the complex [FEF4(OH2)2]¯ ?

A: Co-ordination compound: These are complex compounds that are formed by metal ion to which electron…

Q: The higher the ammonia concentration, the less sharper the end point for the EDTA-Zn²+ complex.

A: No. Of moles of KOH in 26.66ml of 0.15M KOH = (0.15/1000)*26.66 =0.0039 mol No. Of moles of…

Q: The Ir complex Ir(PPH3)2(CO)(Cl)(CH3)I is formed from Vaska's compound and methyl iodide via: Select…

Q: Name these coordination complexes: Cr(NH3 )3Cl3 Pt(en)Cl2 [Pt(ox)2 ]2- [Cr(H2O)5Br]2+…

Q: give the properties of the enzyme (e.g., shape, size, colour, price). a) aluminosilicate b) trypsin

A: In a chemical reaction, the compounds that help to increase the rate of a reaction are called…

Q: Consider the two complexes i) [Cr(OH2)4Cl2]•H2O and ii) [Cr(OH2)sCl]Ci a) Name the two complexes.

A: Since you have posted a question with multiple sub-parts, we will solve subpart "a" as asked by you.…

Q: A protein binds to a ligand with a Ka of 15 x 10 M. At what concentration does e equal 0.75? 0.27 nM…

A: Given information: Kd=15×10-5 Mθ=0.75

Q: A receptor, R, binds to its ligand, L, according to the binding curve shown below. If [R]= 25 mM at…

A: Concentration of ligand= 28mM

Q: The conditional stability constants for the formation of the EDTA complex of Cu2*( KMY=6.3x1018 )at…

A: We are given the formation constant of Cu2+ =6.3×1018 pH=07 α4=5.0×10-4

Q: In which of the following complexes is a Jahn-Teller distortion expected? Select one: a.…

A: The jahn teller effect is a geometric distortion of a non linear molecular system that reduces it's…

Q: Describe the shape and magnetic behaviour of following complexes :(i) [CO(NH3)6]3+(ii) [Ni(CN)4]2-…

A: Given Describe the shape and magnetic behavior of following complexes :(i) [CO(NH3)6]3+(ii)…

Q: Two ligands have 1000-times different affinities for the same binding site. They differ by a single…

A: Given: Two ligands have 1000-times different affinities for the same binding site Let's say ligand…

Q: 54. In the octahedral complex Co(NH2CH2CO2)3, each glycinate ion NH2CH2CO2¯ binds to cobalt through…

A: This question is related to stereochemistry. Stereoisomers are the molecules having the same…

Q: Which of the following is not one of the methods used to determine the stoichiometry of a complex?…

A: a) polarography

Q: Write the chemical equation involved in synthesis of a copper/ammonia coordination complex known as…

A: Coordination compounds are those which do not separate into individual ions when dissolve in…

Q: A Beer's Law plot for a certain colored complex gives the following information. y = 6.85x R2 = 1 If…

A: Beer's Law gives the relation between Absorbance and concentration and is expressed as A=mC+b…

Q: Give the name, the stereochemistry and the magnetic behaviour of the following complexes: (i)…

A: A coordination complex is formed by a metal atom surrounded by ligands. They form a coordinate bond.…

Q: at is the formula of the coordination compound containing anion [Fe(OH)6]3- and ion Na* ? а.…

A: Which one of the following is correct answer

Q: The absolute configuration of the following complex ion is "Delta" + Br Brilll N True False Coll. N…

Q: 3. Use the information in the table below to answer questions 3a and 3b about the Krp protein with…

Q: Give the systematic name for the following coordination compound or complex ion: CI Co3 CI F. F cis-…

A: The geometry of the given complex is square planar.

Q: Some Protein P binds to 1 molecule of X. The fractional binding curve (θ vs. [Ligand]) shows that θ…

A: For binding of ligand to a protein, the fractional saturation (θ) is calculated using Hill equation:…

Q: What's the purpose and the anticipated outcome of the synthesis of a coordination compound POTASSIUM…

A: The purpose and the anticipated outcome of the synthesis of a co-ordination compound potassium…

Q: The H2SB-1 ligand can show tautomerism, i.e., a different arrangement of bonds in the structure. In…

Q: Examine the image of a graph of fraction bound versus ligand concentration. The protein in question…

A: Since you have asked multiple questions, we will solve the first question for you. If you want any…

Q: Consider the donor–acceptor complexes (CH3)3 NSO3 and H3NSO3 in the gas phase. i. Predict which…

A: Inorganic chemistry.

Q: A ligand, [2,4-ditert-butyl-6-{[(2-pyridyl)ethyl](2-hydroxybenzyl)- new aminomethyl}-phenol, was…

Q: In which of the following is the correct designation for the [{Co (NH3) 5} 2 (µ-OH)] 5+ complex in…

Q: Write the name, the structure and the magnetic behaviour of each one of the following complexes :(i)…

A: Magnetic behaviour of any complexes id divided into two categories: Paramagnetic : Those complexes…

Q: A protein binds a ligand with a ka value of 7.4 x 104 M-1s-1 and a kd value of 6.4 x 10-4 s-1. What…

A: For any protein ligand complex, A+B⇌kdkaABKD=kakd where, KD=[AB][A][B], which is the dissociation…

Q: A protein (P) binds a ligand (L) to form a complex (PL). a. Draw the equilibrium expression. b.…

A: Since you have posted a question with multiple sub-parts, we will solve first three subparts for…

Q: 1. b) Briefly explain the transition of electron in charge-transfer complex such as iron…

A: Calculate oxidation state of Fe in Fe( SCN)2+ The charge on thiocyanate is -1 Let the charge on…

Q: (3) The rate constants for the exchange reaction: [Cr(H2O)sX]? + [*Cr(H2O)6]?[*Cr(H2O)sX] +…

Concept explainers

Organometallic compounds of d-block elements

The transition metals can form complexes since they have vacant d orbitals. They are also termed Coordination compounds. The organometallic compounds of the transition metals could be used as catalysts as well as reagents. For example, organocadmium, organozinc, organocopper, Grignard are used as the reagents for several reactions. Most of the complexes of organo transition metals are used as catalysts for many organic transformation reactions.

Question

An enzyme binding equilibrilum has a Kd = 50 mM. What concentration
of ligand (in mM) is required in order to bind 10% of the enzyme?

Expert Solution

This question has been solved!

Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.

SEE SOLUTION Check out a sample Q&A here

Step 1

VIEW

Step 2

VIEW

Step by step

Solved in 2 steps

SEE SOLUTION Check out a sample Q&A here

Knowledge Booster

Organometallic Compounds of d-Block Elements

Learn more about

Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.

Similar questions

Protein X binds to Ligand W with a dissociation constant of .15 μmol. what is the concentration of W 75% of the protein is free (ie, unbound)?"
calculat dlta E for each complex Trans complex : G= 355 microsiemens λ= 450 nm Cis complex : G=250 microsiemens λ=500 nm.
A protein binds a ligand with a KD value of 0.25 M. If you are at a ligand concentration of 0.63 M, what is the fraction bound? Please report your answer to two significant figures. There should be no units in your answer
A protein binds a ligand with a ka value of 7.4 x 104 M-1s-1 and a kd value of 6.4 x 10-4 s-1. What is the KD value of this binding event in units of nM? Please report your answer to two significant figures and include units.
What is the concentration of ligand [L] if this [L] can make 75% of protein bound to it ligand? (kd = 40mM)
Both [Fe(CN)6]4- and [IrCl6]2- exchange their ligands rather slowly, yet the cross reaction between them occurs very rapidly. Propose a mechanism to account for this observation.
Cis-[PtCl2(NH3)2] is a complex commonly known as cisplatin. When the two chloride ligands in this complex are replaced with the bidentate glycolate ligand (OCH2CO22-), it produces nedaplatin. Given this information, answer the following: Full name of the nedaplatin Is the complex paramagnetic? Why or why not?
You prepare a solution of protein and its ligand where the initial concentrations are [Protein] = 10 nM and [Ligand] = 10 nM. At equilibrium you measure the [PL] = 5 nM. If the protein - ligand association can be represented by: P + L <--> PL What is the dissociation constant (Kd) of the protein for the ligand under the solvent conditions you have chosen? a. 1 nM b. 0.2 nM-1 c. 5 nM d. 10 nM
Tp 2Fe is a low-spin Fe(II) complex with Fe-N bonds of 1.97 Å. Tp Ph 2Fe is a similar complex that is high-spin Fe(II) and has Fe-N bonds of 2.25 Å. Explain why the high-spin complex would have longer (i.e., weaker) Fe-N bonds than the low-spin complex.
Q6. a) which of these complexes [CoF6]3- and [Co(en)3]3+ Is high spin and how many unpaired electron are present in each complex? b) which of these ligands is ambidentate or bidentate or monodentate or tridentate? (F-, ethylenediamine, CNS-, NO2-, C2O4H2, Diethylenetriamine).
Describe the state of hybridization, the shape and the magnetic’behaviour of the following complexes: (i) [Cr(H20)2(C204)2]- (ii) [Co(NH3)2(en)2]3+, (en = ethane-1, 2-diamine) (At. Nos : Cr = 24, Co = 27)
Determine the formula for a complex ion with metal ion X+2 and ligand Y-1 from the following Job's plot. A) XY+1 B) XY4-2 C) XY6-4 D) XY5-3 E) XY2 F) XY3-1