An individual has a mutation that prevents the proper formation of lactate dehydrogenase. What is the biggest impact that this will have on this individual's metabolism?
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- Which of the following statements is false?a) there is less energy in 6 molecules of carbon dioxide than in 2 molecules ofpyruvateb) energy can be extracted from pyruvatec) there is more energy in two molecules of pyruvate than in one molecule ofglucosed) there is more energy in pyruvate than lactateWhich of the listed glycolytic enzymes adds a phosphate group to ADP to produce ATP? 1.) pyruvate kinase 2.) hexokinase 3.) phosphofructokinase-1 4.) pyruvate dehydrogenase 5.) phosphexose isomerase 6.) lactate dehydrogenaseWhich of the following is a negative regulator of the pyruvate dehydrogenase complex (PDC)? 1. acetyl CoA 2. ADP 3. pyruvate 4. citrate
- For an individual whose liver is regulated to have gluconeogenesis on and glycolysis off, when energy is needed - what is the major carbon source used to produce acetyl CoA? a. amino acids b. glyoxylate c. glucose d. fatty acidsWhich of the following is NOT a component of the pyruvate dehydrogenase complex? a. dihydrolipoyl dehydrogenase b. dihydrolipoyl transacetylase c. pyruvate dehydrogenase d. dihydrolipoyl catalaseWhich of the following is true concerning the function of lipoic acid in pyruvate metabolism? a. transfer of acetyl groups b. pyruvate decarboxylation c. conversion of pyruvate to lactate d. oxidation of FADH2 to yield NADH
- At high energy charge (ATP/AMP ratio) AND low blood glucose levels a. Pyruvate is converted to glucose via gluconeogenesis b. Glycolysis is activated c. Fatty acids are converted to Acetyl-coA d. Gluconeogenesis is inhibitedIn the last step of glycolysis, phosphoenolpyruvate (PEP) is converted to pyruvate and during this reaction ATP is synthesized. Based on the fact that ATP is synthesized, which of the following enzymes would most likely catalyze this reaction? a. enolase b. pyruvate kinase c. aldolase d. pyruvate isomerase e. pyruvate dehydrogenaseMost defects in pyruvate dehydrogenase complex are due to mutations in ______, so supplements with ______ are given. E2 and TPP E1 and lipoamide E3 and NAD+ E2 and lipoamide E1 and TPP
- Why does epinephrine stimulate glycolysis? I know why epinephrine stimulates glycogenolysis which is to release glucose stores. But epinephrine stimulating glycolysis seems counterintuitive as it would synthesize less glucose and more pyruvate?What is the first cofactor to accept electrons from pyruvate in the Pyruvate dehydrogenase complex? Thymine pyroposphate lipoyllysine FAD NAD⁺___ molecules of ATP are ultimately formed per every acetyl-CoA that enters the citric acid cycle and the remaining ATP molecules are generated via the ___ of NADH and FADH2. A) Nine; oxidation B) Ten; reduction C) Ten; oxidation D)Nine; reduction