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- Which factors would favor an SN2 reaction? Choose one or more: A. a strong nucleophile B. a good leaving group C. a high concentration of nucleophileWhich of the alternatives describes the best reaction condition to favor bimolecular nucleophilic substitution reaction in the presence of 2-bromo-3-methyl-butane? * a) weak nucleophile in protic solvent b) weak nucleophile in aprotic solvent c) strong nucleophile in protic solvent d) strong nucleophile in aprotic solvent e) the substrate does not undergo nucleophilic substitution reactionWhich of the following conditions favor the reaction of alkyl halides via SN1 mechanism? Group of answer choices -polar protic solvents, weak nucleophiles -polar aprotic solvents, weak nucleophiles -polar aprotic, strong nucleophiles -polar protic, strong nucleophiles
- In the first step of a Wittig reaction, what will happen if you use chlorobenzene instead of benzyl chloride? Why a) the yield will increase, because chlorobenzene is a better nucleophile b) yield will be slightly decreased, because chlorobenzene is a poorer nucleophile c) no product will form, chlorobenzene cannot be converted to a phosphonium chloride salt d) no alkene product will form the phosphonium salt from chlorobenzene reacts with chloro benzene to form triphenyl magnesium chloride. e) no noticable change will be detected, benzyl chloride and chlorobenzene are essentially the same compoundsIdentify the stronger nucleophile in each pair of anions. a.Br− or Cl− in a polar protic solvent b.HO− or Cl− in a polar aprotic solvent c.HS− or F− in a polar protic solventDrawing an SN1 Mechanism That Involves a Rearrangement Draw a stepwise mechanism for the following reaction.
- Which of the alternatives describes the best reaction condition to favor bimolecular nucleophilic substitution reaction in the presence of 3-methyl-butane? *a) weak nucleophile in protic solventb) weak nucleophile in aprotic solventc) strong nucleophile in protic solventd) strong nucleophile in aprotic solvente) the substrate does not undergo nucleophilic substitution reaction.Which reagent in each of the following pairs is more nucleophilic? a) (CH3)3B and (CH3)3N b) H2O and H2S c) NH3 and H2ODraw a stepwise mechanism for the following reaction that illustrates how two substitution products are formed. Explain why 1-bromohex-2-ene reacts rapidly with a weak nucleophile (CH3OH) under SN1 reaction conditions, even though it is a 1° alkyl halide.
- An SN2 mechanism takes place when 3-(bromomethyl)pentane is added to each nucleophile listed below. Which nucleophile will also require an acid-base step after the substitution step in order to produce a neutral (not charged) product? A. LiN(CH3)2 B. NaI C. KN3 D. HSCH3 (Please type answer no write by hend)What is the product of the SN2 reaction of (R) 3-bromo-2-methylhexane with CH3CO- Select one: a. (S) 2-methyl-3-ethoxy-hexane b. (S) 2-methyl-2-ethoxy-hexane c. (S) 3-methyl-2-ethoxy-hexane d. (S) 2-methy-3-hexanol e. (R) 2-methy-3-hexanolRank the nucleophiles in each group in order of increasing nucleophilicity. a.−OH, −NH2, H2O b.−OH, Br−, F− (polar aprotic solvent) c.H2O, −OH, CH3CO2−
