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At what pH should imine formation be carried out if the
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- Can any functional groups on Risperidone ionize? If so, which ones? Under what conditions? What are the pKa values of these functional groups? Write the structures in their correct ionization state at physiological pH.How would the pKa values of carboxylicacids, alcohols, ammonium ions 1RNH32 + , phenol, and an anilinium ion 1C6H5NH32 + change if they were determined in a solvent less polar than water?Most of the pKa values given in this text were determined in water. How would the pKa values of carboxylic acids, alcohols, ammonium ions (RN+H3) , phenol, and an anilinium ion (C6H5N+H3) + change if they were determined in a solvent less polar than water
- 1a) Biotin has a single ionizable group with a pKa of 4.5. If you dissolved biotin in an aqueous solution at pH 7.0, would this ionizable group be protonated or deprotonated? Briefly explain why the molecule would be in that form at pH 7.0.Use the value of the pK1 provided to deduce the structures of the following oxo acids. Acid pK1 H5IO6 2 H3PO2 2Explain the observed difference in the pKa values of the conjugate acids of amines A and B.
- Which of the following acid/conjugate base pairs has a pKa value of 9.44? A. Ammonium/ammonia B. carboxylic acid/carboxylate C. imidazolium/imidazoleThe pKa, of the conjugate acid of morpholine is 8.33. (a) Calculate the ratio of morpholine to morpholinium ion in aqueous solution at pH 7.0. (b) At what pH are the concentrations of morpholine and morpholinium ion equal?Dicarboxylic acids have two dissociation constants, one for the initial dissociation into a monoanion and one for the second dissociation into a dianion. For oxalic acid, HO2C—CO2H, the first ionization constant is pKal = 1.2 and the second ionization constant is pKa2 = 4.2. Why is the second carboxyl group far less acidic than the first?
- Define the Mechanism - Conversion of Carboxylic Acids to Amides with DCCExplain the reactions involved in separation of p-nitroaniline from mixture contain 3 components 1.Benzoic acid (acidic nature pKa=4.17) 2.Naphthalene (neutral compound) 3.paraNitroaniline(basic compound pKa=12.99Which has a lower pKa value, the conjugate acid of 3-bromoquinuclidine or the conjugate acid of 3 -chloroquinuclidine?