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Calculate the net charge of the molecule at pH 3. net charge at pH 3: Calculate the nct charge of the molecule at pH 8. net charge at plH 8: Calculate the net charge of the molecule at pH 11. net charge at plH 11:

Calculate the net charge of the molecule at pH 3. net charge at pH 3: Calculate the nct charge of the molecule at pH 8. net charge at plH 8: Calculate the net charge of the molecule at pH 11. net charge at plH 11:

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Resources A peptide has the sequence Glu-His-Trp-Ser-Gly-Leu-Arg-Pro-Gly The pk, valucs for the peptide's side chains, lerminal amino groups, and carboxyl groups are provided in the table. Amino acid Amino pk Carboxyl pk Side-chain pK. glutamate histidine 9.60 234 425 9.17 1.82 6.00 tryptophan 9.39 2.38 scrine 9.15 2.21 glycine 9.60 2.34 leucine 9.60 2.36 arginino 9.04 2.17 12.48 proline 10.96 1.99 Calculate the net charge of the molecule at pH 3. net charge at pH 3: Calculate the net charge of the molecule at pH 8. net charge at pH 8: Calculate the net charge of the molecule at pH 11 net charge at pH 1: Estimate the isoclectric point (pl) for this peptide. pl: 46% 75°F Mos hp
Transcribed Image Text:Resources A peptide has the sequence Glu-His-Trp-Ser-Gly-Leu-Arg-Pro-Gly The pk, valucs for the peptide's side chains, lerminal amino groups, and carboxyl groups are provided in the table. Amino acid Amino pk Carboxyl pk Side-chain pK. glutamate histidine 9.60 234 425 9.17 1.82 6.00 tryptophan 9.39 2.38 scrine 9.15 2.21 glycine 9.60 2.34 leucine 9.60 2.36 arginino 9.04 2.17 12.48 proline 10.96 1.99 Calculate the net charge of the molecule at pH 3. net charge at pH 3: Calculate the net charge of the molecule at pH 8. net charge at pH 8: Calculate the net charge of the molecule at pH 11 net charge at pH 1: Estimate the isoclectric point (pl) for this peptide. pl: 46% 75°F Mos hp
Each ionizable group of an amino acid can exist in onc of two states, charged or ncutral The clectric charge on the functional group is determined by the relationship between its pk, and the pH of the solution. This relationship is described by the Henderson-Hasselbalch oquation. Histidine has thrce ionizable functional groups. Complete the cquilibrium oquations by assigning the proper pk, for cach ionization and the net charge on the histidine molecule in cach ionization stale." HN-C-C-0H HN-C-C-o H.N-C-C-o H. HN-C-C-o CH, CH, CH, CH, 12 HN pk, -6.0 PK,-17 NH NH NH 2 Answer Bank pk, - 18 Incomect Match the predominant ioniration state of histidine at pH1. 4. 8. and 12. Note that the ionization state can be approximated by trcating cach iconizable group independently pl14 pil 12 hp
Transcribed Image Text:Each ionizable group of an amino acid can exist in onc of two states, charged or ncutral The clectric charge on the functional group is determined by the relationship between its pk, and the pH of the solution. This relationship is described by the Henderson-Hasselbalch oquation. Histidine has thrce ionizable functional groups. Complete the cquilibrium oquations by assigning the proper pk, for cach ionization and the net charge on the histidine molecule in cach ionization stale." HN-C-C-0H HN-C-C-o H.N-C-C-o H. HN-C-C-o CH, CH, CH, CH, 12 HN pk, -6.0 PK,-17 NH NH NH 2 Answer Bank pk, - 18 Incomect Match the predominant ioniration state of histidine at pH1. 4. 8. and 12. Note that the ionization state can be approximated by trcating cach iconizable group independently pl14 pil 12 hp
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