CH3 CH3 CpG island Core promoter CH3 CH3 CH3 Enhancer CpG island Core promoter CH, Chromatin in an open conformation A methyl-CpG-binding protein binds to the methylated CpG Island. Activator Coding sequence protein Methylation CH3 ÇH3 CH, CH, CH3 CH CH3 CH, CH CH CH сн, сн, сн, Methyl groups block the binding of an actvator protein to an enhancer element. Methyl-CpG- binding protein The methyl-CpG-binding protein recrults other proteins, such as histone deacetylase, that convert the chromatin to a closed conformation. Chromatin (a) Methylatlon Inhibits the binding of an activator proteln. In a dosed conformation CH, CH, CH, CH CH3 CH3 CH, Histone deacetylase (b) Methyl-CpG-binding proteln recrults other protelns that change the chromatin to a closed conformation.

CH3 CH3 CpG island Core promoter CH3 CH3 CH3 Enhancer CpG island Core promoter CH, Chromatin in an open conformation A methyl-CpG-binding protein binds to the methylated CpG Island. Activator Coding sequence protein Methylation CH3 ÇH3 CH, CH, CH3 CH CH3 CH, CH CH CH сн, сн, сн, Methyl groups block the binding of an actvator protein to an enhancer element. Methyl-CpG- binding protein The methyl-CpG-binding protein recrults other proteins, such as histone deacetylase, that convert the chromatin to a closed conformation. Chromatin (a) Methylatlon Inhibits the binding of an activator proteln. In a dosed conformation CH, CH, CH, CH CH3 CH3 CH, Histone deacetylase (b) Methyl-CpG-binding proteln recrults other protelns that change the chromatin to a closed conformation.

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter29: Transcription And The Regulation Of Gene Expression

Section: Chapter Questions

Problem 13P

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