CI Assume the partition coefficient for this compound is too high. Propose a structural modification that would lower the partition coefficient, while not breaking the rules (Lipinski's rules)for total numbers of hydrogen bond donors/acceptors or the rule for molecualar weight.

Q: Thalidomide is a chiral molecule and it was identified that the R-isomer produced the sedative…

A: Thalidomide is a chiral molecule and it was identified that the R-isomer produced the sedative…

Q: Suggest a reason why decane1CH3CH2CH2CH2CH2CH2CH2CH2CH2CH32 does not exhibitliquid crystalline…

A: Since to exhibit liquid crystalline behaviour the molecules should not tend to coil in any random…

Q: Please explain the significance of Wohler’s synthesis of urea in his lab without copying from the…

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Q: Which layer will quinine partition into? Which layer will nootkatone partition into? aqueous or…

A: A mixture of solvents or liquid compounds can be separated using a separating funnel . Compounds…

Q: c. Would it be possible to separate carvone and limonene using just hexanes as the eluent (never…

A: Structure of carvone polar because of the retone group Structure of limonene   Non-polar

Q: The separate enantiomers. of 2-hydroxyheptanoic acid were needed for determination of the absolute…

A: Given reagent is (R) or (S)-malic acid.

Q: How do u account for the observed solubility of C10H8 and urea in H2O based on the nature of the…

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Q: Give the reason(s) of the following statements: 1. t-Butyl > isopropyl > ethyl > methyl for relative…

A: As per our guidelines we are supposed to answer only one question. Kindly repost other questions as…

Q: Give the reason(s) of the following statements: t-Butyl > isopropyl > ethyl > methyl for relative…

A: 1. In the Wagner-Meerwein rearrangement, a carbocation intermediate is formed, the group adjacent to…

Q: Show the degrees of unsaturation of xanthine.

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Q: Which condition will result in faster ring-opening kinetics? Briefly rationalize your answer.

A: In the given problem we need to discuss in which condition (in the presence of TBD or DBU) the ring…

Q: ii) Write a reaction to illustrate B-cleavage of secondary hepthyl radical H3CH2CH2CH2CH•CH2CH3).

A: The above reaction is an example of radical cleavage reaction leading to formation of another…

Q: Identify the electrophilic centre that is attacked on the structure of parecoxib. For this question…

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Q: Give the stereochemical outcome for each of the followingreactions and assign the stereochemical…

A: The given reagent PCC is used to convert primary alcohol to aldehyde and secondary alcohol to…

Q: Why is there a need to wash the residue (which could be CaC2O4) twice with water before the addition…

A: Answer - According to the question - The washed liquid must be a substance which does not interfere…

Q: What would the product of this reaction be? Clearly indicate the configuration of all…

A: Since the NaOMe is a base  Hence along with heat it will extract a H from the reactant and hence…

Q: Secondary (2°) and 3° alcohols react by an SN1 mechanism, socracemization occurs at a stereogenic…

A: SN1 reaction It is known as substitution nucleophilic unimolecular reaction It processes through…

Q: Select a suitable solvent for analysis of one of these terpenes by UV spectroscopy. Explain your…

A: The solvents for analysis of one the terpenes by UV spectroscopy  does not absorb above the 210 nm…

Q: No. of secondary hydrogens No. of tertiary carbons No. of tertiary hydrogens No of quaternary…

A: Quarternary carbon can be defined as the carbon atom which is attached to four other carbon atoms.

Q: CN and ČN

A: Diaxial interaction (1,3-diaxial interaction): An interaction (usually repulsive) between two axial…

Q: An interesting binding phenomenon is sometimes found between nitro groups and halogens on aryl…

A: A halogen bond is a type of noncovalent interaction that encompasses a wide range of interactions.…

Q: According to the IR spectrum what is the major product of the reaction sequence shown in the box?…

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Q: b) expect it to be more soluble? Explain. Please be specific. When 1-phenylcyclohexanol is…

A: A substance is more soluble in a solvent which is similar to it in nature. Diethyl ether and water…

Q: On the basis of the tlc results, explain how you would you be able to argue that acetanilide you…

A: Interpretation-  To explain that how on the basis of TLC results we will able to argue that…

Q: UV, IR, and MS (Interpretation of Structure) 1.) Predict the structure of the two unknown…

A: 1. Odd mass, odd no of nitrogens present. Therefore one nitrogen present. Therefore the compound…

Q: Interpret  the 1H NMR spectral  provided for the Suzuki Cross-Coupling Reactions: Synthesis of an…

A: Suzuki coupling the coupling of the organohalides and organobornes in the presence of palladium…

Q: Lactose and also maltose hydrolyzes upon prolonged heating and gives positive result with…

A: Seliwanoff's Test It is a test to determine aldose(containing aldehyde group) and ketose(containing…

Q: Write the mechanism for the nitration at the ortho position of methyl benzoate with nitric acid and…

A: Methyl benzoate is a meta director. Thus nitration of methyl benzoate is only possible at meta…

Q: Show hoe the Cahn-Ingold-Prelog sequence rules are used to assign the configuration of the…

A: Cahn-Ingold-Prelog rules are used to assign configuration to a chiral carbon in a molecule. A chiral…

Q: Make an electron-flow-mechanism for this synthetic scheme. This involves predicting major and…

A: The carboxylic acid functional group is represented by R-COOH, where R can be an alkyl or aryl…

Q: In the sunthesis of Dibenzalacetone why must there be 2x the amount lmoles) of henzaldehyde. Land…

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Q: Discuss comprehensively whether the circled functional group is an activator or deactivator during…

A: A question based on substitution aromatic electrophilic reaction, which is to be accomplished.

Q: Mention in case there are differences in physicochemical parameters of the enantiomers. 2. Mention…

A: Hello. Since more than one question has been asked, the first question shall only be answered in…

Q: Draw the structure of a compound with molecular C8H14 that reacts with one equivalent of H2 over…

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Q: A student planned to utilize HPLC to separate her chemically synthesized product (1) from th…

A: HPLC stands for High Performance Liquid Chromatography which is used to separate and identify…

Q: Show the position of any electron lone pairs in this structure of acetamide, and indicate the…

A: From the given structure the molecular formula of the compound is -  C2H5NO The total valance…

Q: Illustrate the effects of conjugation on the location of the carbonylabsorption in some…

A: The transfer of double bond from a beta carbon of the double bond to the carbonyl group gives rise…

Q: Please provide the chair conformation for the fallowing.   trans-2-methylcyclohexyltosylate…

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Q: Interpret the results of the UV-vis spectra and briefly explain why the 3-phenylpropionaldehyde…

A: UV-visible spectroscopy is an absorption spectroscopy. It uses light in visible regions and adjacent…

Q: State the difference between the reaction that occur when isopropyltriethylammonium hydroxide is…

A: Let us try to study both the reactions one by one and then we can note differences between them.

Q: The use of sodium iodide in acetone promotes SN2 mechanism for alkyl halide resulting in the…

A: Sn2 reaction is favored in nonpolar solvent.

Q: What is the changes in TZDs (specifically pioglitazone) structure that has direct impact in clinical…

A: The thiazolidinediones are TZDs or glitazones belong to a class of antidiabetic drugs and improve…

Q: Construct a 9-point cycle that has a carboxylic acid and an ene as functional group. Name by IUPAC…

A: A 9-point cycle is a cyclic compound containing nine carbon atoms.  The carboxylic acid functional…

Q: acylation. why does the synthesized compound exhibited fluorescence activity. and which layer in the…

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Q: Find the attached question

A: The OEt- in the presence of EtOH trap the α-hydrogen and forms the enolate ion.

Q: Compound U is an aldopentose that can be oxidized to an optically inactive aldaric acid V. Upon…

A: Structures for compound U to Z are

Q: Draw the correct stereochemical structures of these two compounds of the fumarase-catalyzed…

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Q: Draw and upload a separation scheme for the isolation of isopentyl acetate from the reaction…

A: We have to Draw a separation scheme for the isolation of isopentyl acetate from the reaction…

Photochemistry

Photochemistry is the part of chemistry that studies the various mechanisms of reactions that are triggered by the presence of light energy. It also helps to study the changes involved in a molecule that can undergo the absorption of radiation.