Cis-diamminedichloroplatinum (II) or “cisplatin” is a square planar complex with the formula [Pt(NH3)2Cl2]. Cisplatin is an anticancer drug that works by bonding to two adjacent guanine bases on the same strand of DNA, creating a kink which disrupts DNA replication. Each bond to a guanine base is formed by displacing one Cl ligand on cisplatin. The closely related complex trans-diamminedichloroplatinum (II) is completely ineffective as an anticancer agent. Explain why
Atomic Structure
The basic structure of an atom is defined as the component-level of atomic structure of an atom. Precisely speaking an atom consists of three major subatomic particles which are protons, neutrons, and electrons. Many theories have been stated for explaining the structure of an atom.
Shape of the D Orbital
Shapes of orbitals are an approximate representation of boundaries in space for finding electrons occupied in that respective orbital. D orbitals are known to have a clover leaf shape or dumbbell inside where electrons can be found.
Cis-diamminedichloroplatinum (II) or “cisplatin” is a square planar complex with the formula [Pt(NH3)2Cl2]. Cisplatin is an anticancer drug that works by bonding to two adjacent guanine bases on the same strand of DNA, creating a kink which disrupts
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