Control wells in the dopamine assay normally look like this: dopamine HVA Legend: = high (dopamine low (or no) (dopamine neural cells If the researchers accidentally added neural cells to all of the wells, what would the control wells look like?
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- Identify the structure highlighted in green: Epinephrine receptor ACh receptor Norepinephrine receptorEpilepsy is often treated with a combination of drugs such as carbamazepine and phenytoin (polytherapy). CYP3A4 is induced by phenytoin and carbamazepine. Carbamzeipine is cleared by CYP3A4, but phenytoin is not cleared by CYP3A4. What problems might you expect if (a) carbamazepine is removed or (b) phenytoin is removed from this two-drug regimen.Is EGFR and KRAS involved in lung cancer brain metastasis? Explain.
- Afatinib is an effective first-line treatment for patients with EGFR-mutant NSCLC. Research groups designed and synthesized afatinib analogs to increase the inhibitory effect against EGFR and VEGFR2/KDR kinases. Meo. OMe Br HN HN OMe Afatinib Compound I Compound II The researchers run a series of tests to explore the kinase inhibitory activity of Afatinib and Compound I with EGFR. They found the IC50 of Compound I is 3.6 nM and that of Afatinib is 1.6nM. a. Please briefly explain the effectiveness of Compound I compare to Afatinib based on the information givenWhat are the superiorities of PPI over H2 blocker? How Omeprazole acts? Please briefly explain at your own words.Aducanumab is a human antibody treatment strategy currently undergoing phase III clinical trials in Alzheimer’s disease. This acts by: (choose all that apply) increasing cholinergic stimulation selectively inhibiting serotonin stimulating dopamine receptors reducing the production of Aβ plaques promoting neurogenesis reducing neurofibrillary tangles
- Which of the following would you expect to happen if amino acids 579 to 582 (YIYV) in the PDGF-Beta receptor were exchanged with amino acids 992 to 995 (YLIP) from the EGF receptor to give PDGF (YLIP) and EGF (YIYV) (Select all that apply)? (A) PDGF-B receptor Src I NCK-B SHP2 PLC-y P 579 P 581 YIYV PI3KY P 740 YMDM NCK-a P 751 YVPM P 771 YMAP GAP P 1009 YTAV P 1021 YIIP (B) POE 845 YHAE 992 YLIP 1045 YSSD 1068 YINQ 1086 YHNK 1148 YQQD 1173 YLRV P P P P P P P EGF receptor STAT3/5 PLC-y Shc Cbl JAK2 Grb2 STAT3/5 Shc SHP1 PTP1Using molecular cloning, a hybrid receptoer is produced that consists of the extracellular domain of the B-adrenergic receptor (B-AR) and the transmembrane and intracellular domains of the EGF receptor (EGFR). Question: What is the stoichiometric ratio of epinephrine to the hybrid receptor (B-AR-EGFR)? 1:1 O 1:4 O 1:2 2:1 O O OThree potential inhibitors for VEGF were discussed in the signal transduction simulation. Explain two possible steps that these drugs can be expected to interfere with VEGF signaling (Hint: think about the requirements for signaling to occur).
- Which of the following would you expect to happen if amino acids 579 to 582 (YIYV) in the PDGF-Beta receptor were exchanged with amino acids 992 to 995 (YLIP) from the EGF receptor to give PDGF (YLIP) and EGF (YIYV) (Select all that apply)? (A) (B) PDGF-B receptor Src $8 & P 579 P 581 YIYV PI3KY P 740 YMDM NCK-a P 751 YVPM P 771 YMAP GAP NCK-B SHP2 PLC-y P P 1009 YTAV 1021 YIIP ala 845 YHAE 992 YLIP P 1045 YSSD 1068 YINQ 1086 YHNK 1148 YQQD P 1173 YLRV P P P P P EGF receptor STAT3/5 PLC-y Shc Cbl JAK2 Grb2 STAT3/5 Shc SHP1 PTP1GTPYS is a nonhydrolyzable analog of GTP. Suppose this compound were added to a cell-free system containing active components of an adrenergic signaling system. What consequences would you expect? What would be the effects on CAMP levels? || -0-P-o-P-0-P-o-CH, guanine он он GTPYS -Pls explain in detail how the drug affected brain cells at the cellular or molecular level (do not just copy and paste on internet) Please write the details of each one Meth Opiate Receptor GABA Receptors Dopamine Receptor