Cp(mg/L) 25 20- 15- 10- 5- 2 A 10 Cp(mg/L) 25- 20- 15- 10- 5- 2 B 10 Time (h) Time (h) Comparison of kaurenoic acid plasma decay (dose = 50 mg/kg). (A) Intravenous route. (B) Oral route.
Cp(mg/L) 25 20- 15- 10- 5- 2 A 10 Cp(mg/L) 25- 20- 15- 10- 5- 2 B 10 Time (h) Time (h) Comparison of kaurenoic acid plasma decay (dose = 50 mg/kg). (A) Intravenous route. (B) Oral route.
Chapter5: Calculating Adult Dosages: Oral And Parenteral Forms
Section: Chapter Questions
Problem 2SA
Related questions
Question
Transcribed Image Text:Kaurenoic acid is an active ingredient found in
various plants, including stevia.
Scientists investigated the pharmacokinetic profile
of 50 mg/kg of kaurenoic acid in rats after
intravenous (IV) vs oral administration. The plots
below were obtained.
Cp(mg/L)
25
20-
15-
10-
0
2
•
4
A
8
Cp(mg/L)
10
25-
20-
15-
6
6
Time (h)
Time (h)
Comparison of kaurenoic acid plasma decay (dose = 50 mg/kg). (A) Intravenous route. (B) Oral route.
10-
5-
0+
0
4
B
8
10
The IV plot could be fitted by the equation:
Cp = 28 exp(-1.2t) - where Cp (mg/L) is the plasma
concentration and t (h) the time after administration
of a 50 mg/kg single dose.
Transcribed Image Text:1) Briefly discuss whether kaurenoic acid activity is
to be expected from commercial 150 mg stevia
capsules.
2) From the IV results, determine the parameters
listed below. Provide the final formula used and
correct units.
- Apparent volume of distribution (per kg of body
weight);
- Half-life;
- Clearance (per kg of body weight).
3) Briefly discuss whether the parameters you
calculated apply to both routes of administration
Expert Solution
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
Step by step
Solved in 2 steps
Recommended textbooks for you