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- Describe two roles for polyubiquitinylation in the NF-κB signaling pathwayMuch of what we know about cell signalling comes from biochemical studies of proteins isolated in test tubes. What is the precise quantitative behaviour of intracellular signalling networks in an intact cell where countless other signals and cellular components can influence the specificity and intensity of signalling?Provide a diagram of the EPH RECEPTOR B2 (EPHB2) structure. Give bioinformatics structure
- Describe the intracellular, biochemical downstream signal cascade that results from the binding of menthol to TRPM8BIOC 384 G Protein-Coupled Receptor (GPCR) Signaling Q.7.3: Glucagon and epinephrine both signal stress, which would be low blood glucose levels or acute danger, respectively. Describe the upstream signaling pathways that would be activated in liver cells if you were hungry from a long hike in Sabino Canyon and came across the biggest rattlesnake you had ever seen right in front of you on the trail.Below is a diagram of the canonical Wnt signalling pathway. Numbers 1-7 refer to different molecules involved in the pathway. In addition to the main pathway components depicted above, outline some of the mechanisms that allow Wnt signalling to be ‘fine-tuned’.
- Explain in detail the funcations and signalling and activation of ephrin receptor EPHB2. Give step by step explanationexplain the following prperties of G protein: structure of G- activation cycle and signaling pathway for GaqDiscuss the regulation, role, and cellular localisation of named protein kinases active in specified G protein-coupled receptor signalling pathways.
- CTP inhibits ATCase; however, the inhibition is not complete. Can you suggest another molecule that might enhance the inhibition of ATCase?Describe the mechanisms that limit signaling by the phosphoinositide pathway.Ion channel-coupled receptors • G-protein-coupled receptors • Enzyme-linked receptors • Briefly describe what a G-protein is (explain by using the words GTPase, GTP and GDT) • Briefly describe how a G-protein-coupled receptor for the signal / information further into • Briefly describe how an enzyme-linked receptor carries the signal / information further into the cell.