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- Discuss the following statement: “We wouldhave no idea today of the importance of insulin as a reg-ulatory hormone if its absence were not associated withthe human disease diabetes. It is the dramatic conse-quences of its absence that focused early efforts on theidentification of insulin and the study of its normal role inphysiology.”Distinguish the difference of the mechanism of insulin insufficient DM and insulin resistance DM.Greg Tobin mixes together three types of vitamintablets. Each Super Vim tablet contains, among other things,15 mg of niacin and 12 I.U. of vitamin E. The figures for aMultitab tablet are 20 mg and 15 I.U., and for a Mighty Mix are25 mg and 35 I.U. How many of each tablet are there if the totalnumber of tablets, total amount of niacin, and total amount ofvitamin E are as follows?a. 225 tablets, 4750 mg of niacin, and 5225 I.U. of vitamin Eb. 185 tablets, 3625 mg of niacin, and 3750 I.U. of vitamin Ec. 230 tablets, 4450 mg of niacin, and 4210 I.U. of vitamin E
- Discuss, in terms of AMPK activity and GLUT4, how physical inactivity might lead to insulin resistance.Discuss the differences in plasma glucose contents, plasma β-hydroxybutyrate contents and plasma insulin contents among the normal feed rats, 24 hr starved rats and 48 hr starved rats.Brieflyexplainthesignalingpathwaybywhichthelivercovertsthestoredcarbohydrateto glucose and transports it to blood at low blood glucose level. In your answer, the signal pathway, source of glucose, key enzymes and proteins should be described.
- Evidence from animal experiments and epidemiological studies indicates that the risk of obesity rises with increasedb isphenol-A (BPA) intake. How might the endocrine-disrupting effects of such a chemical influence body weight?Using the PICO example “In diabetic males over 45, will a vegan diet or vegetarian diet improve insulin levels?”, what is the outcome to be measured?Which of the following statements about insulin istrue?a. Insulin acts as a transport protein, carryingglucose across the cell membrane.b. Insulin facilitates the movement of intracellularglucose transporters to the cell membrane.c. Insulin stimulates the breakdown of storedglycogen into glucose.d. Insulin stimulates the kidneys to reabsorbglucose into the bloodstream
- what are the meaningof biosensor term, and explain how the biosensor might be used to be control insulin release in a person with diabetes?What is typically seen with biguanide use?A. Increased glucose uptake by muscle tissueA. Decreased basal insulin levelB. Decreased intestinal glucose absorption C. Gastrointestinal disturbancesD. Decreased lactate levelDiabetes mellitus is characterized by insufficiency of thepancreas to produce enough insulin to regulate the blood sugarlevel. In type I diabetes, the pancreas produces no insulin, andthe patient is totally dependent on insulin from an externalsource to be infused at a rate to maintain blood sugar levelsat normal levels. Hyperglycemia occurs when blood glucoselevel rises much higher than the norm (>8 mmol/L) for pro-longed periods of time; hypoglycemia occurs when the blood sugar level falls below values of 3 mmol/L. Both situations canbe deleterious to the individual’s health. The normal range ofblood sugar is between 3.8 and 5.6 mmol/L, the target rangefor a controller regulating blood sugar.A patient with type I diabetes needs your help to maintainher blood sugar within an acceptable range (3 mmol/L<glucose<8 mmol/L). She has just eaten a large meal (a disturbance) that you estimate will release glucose accord-ing toD(t)=0.5e−0.05t,wheretis in minutes andD(t)is inmmol/L –…