Different mutations in the WDR62 gene that inactivate gene function were found in the genomes ofmany different people with microcephaly. This information provided strong support for the idea that theWDR62 gene mutation causes microcephaly.a. The human genome sequence identified WDR62as one of the approximately 27,000 genes in thehuman genome. What information about the functionof WDR62 do you think was learned originallyfrom the DNA sequence of the normal humangenome?b. What additional information was provided byidentification of WDR62 as the microcephalydisease gene?c. The mouse genome contains a gene similar to human WDR62. Experiments in mice have shownthat the mouse WDR62 gene is expressed in thebrain. Technology is now available that allows scientists to generate mice in which the two normalcopies of the WDR62 gene are replaced with mutant copies of the gene that are nonfunctional. Whywould a scientist want to generate such WDR62mutant mice?
Different mutations in the WDR62 gene that inactivate gene function were found in the genomes of
many different people with microcephaly. This information provided strong support for the idea that the
WDR62 gene mutation causes microcephaly.
a. The human genome sequence identified WDR62
as one of the approximately 27,000 genes in the
human genome. What information about the function
of WDR62 do you think was learned originally
from the DNA sequence of the normal human
genome?
b. What additional information was provided by
identification of WDR62 as the microcephaly
disease gene?
c. The mouse genome contains a gene similar to human WDR62. Experiments in mice have shown
that the mouse WDR62 gene is expressed in thebrain. Technology is now available that allows scientists to generate mice in which the two normal
copies of the WDR62 gene are replaced with mutant copies of the gene that are nonfunctional. Why
would a scientist want to generate such WDR62
mutant mice?
Trending now
This is a popular solution!
Step by step
Solved in 3 steps
