e. More than 82% QUESTION 11 You have sequenced mRNAs from an esophogeal cancer tumor and mRNAS from matched healthy tissue. You plot the number of RNA sequencing reads (shown below). Where in the graph (A-D) would you find genes that are underexpressed in the cancer cells? Number of Sequencing Reads per gene (1000's) (A)* (B) (D) 10 12 Cancer Tissue O a. (B) O b. (A) O c. You can not determine that from this information. O d. (C) O e. (D) QUESTION 12 Consider a hypothetical beetle whose back abdomen pattern is determined by two alleles A1 and A2. Beetles that are homozygous for the 'A1' allele have solid coloring, beetles that Click Save and Submit to save and submit. Click Save All Answers to save all answers. ********* stv Healthy Tissue 14 Sav

e. More than 82% QUESTION 11 You have sequenced mRNAs from an esophogeal cancer tumor and mRNAS from matched healthy tissue. You plot the number of RNA sequencing reads (shown below). Where in the graph (A-D) would you find genes that are underexpressed in the cancer cells? Number of Sequencing Reads per gene (1000's) (A)* (B) (D) 10 12 Cancer Tissue O a. (B) O b. (A) O c. You can not determine that from this information. O d. (C) O e. (D) QUESTION 12 Consider a hypothetical beetle whose back abdomen pattern is determined by two alleles A1 and A2. Beetles that are homozygous for the 'A1' allele have solid coloring, beetles that Click Save and Submit to save and submit. Click Save All Answers to save all answers. ********* stv Healthy Tissue 14 Sav

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Description: 11 e. More than 82%QUESTION 11You have sequenced mRNAs from an esophogeal cancer tumor and mRNAs from matched healthy tissue. You plot the number of RNA sequencing reads (shown below). Where in thegraph (A-D) would you find genes that are underexpres

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter12: Genes And Cancer

Section: Chapter Questions

Problem 13QP: The search for the BRCA1 breast cancer gene discussed in this chapter was widely publicized in the...

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49. For gene expression profiling, what does a microarray or “gene chip” measure directly? Group of answer choices The amount of expressed proteins The number of copies of a gene The amount of transcribed mRNAs The rate at which cells divide
Give only typing answer with explanation and conclusion Recombinant human insulin produced by bacteria carrying a cloned insulin gene, is now the major form of insulin used to treat diabetes. The human insulin gene encodes an mRNA only 333 nucleotides long, but the entire gene spans more than 4000 nucleotides. There are three exons and two introns 1. Every cell in the human body has the same DNA, so very cell has an insulin gene. However in order to use the technique, you described in b, you would have to start with cells from the pancreas the only body cells that actually produce the insulin protein. Why are these the only cells that would work.
Question:- Changes affecting tumor suppressors generally require _____ alleles to be affected in order to trigger transformation. one five or more two zero
Mutational signatures of p53 are shown in this image (G.P. Pfeifer et al., Nature, 21(48), 2002) for the three types of cancer with the highest death rates in the United States: lung (~225,000 deaths in 2016), breast (246,000), and colorectal (381,000). These data can be obtained by sequencing the gene that encodes p53. Approximately 85 percent of lung cancers occur in smokers. Based on these data, calculate how many deaths due to lung cancer among nonsmokers were reported in 2016. How much does smoking increase the likelihood of death due to lung cancer?
Give typing answer with explanation and conclusion a) List three eukaryotic gene expression mechanisms that do not occur in prokaryotes. For two of these, give specific examples and the functional outcomes. b) Describe what is meant by the term “RNA silencing”. c) Using diagrams, give two examples of RNA silencing mechanisms and indicate one difference.
In the treatment of cancer, the basis for many types of chemotherapyand radiation therapy is that mutagens are more effective at killingdividing cells than nondividing cells. Explain why. What are possibleharmful side effects of chemotherapy and radiation therapy?
1- You are studying lung cancer and use a microarray to compare gene expression between a lung cancer tumor and healthy adjacent lung tissue. If you label vour cancer cDNAwith red fiuorescence and your normal tissue with green, what color would you expect tumor suppressors to be:© a. GreenU D. RedOc.No color) d. Either Red or Green© e Yellow 2- You want to study histone modifications using Next Generation sequencing. What technique would allow you to do this?© a, Sanger sequencing© b. Fluorescence in situ hybl© c. RNA-SeqOld. ChIP-sed© e. Poymerase Chain Reaction 3-Gertrudae mcfuzzi is a rare (and ficticious) species of bird with colorful tail feathers. All Gertrude mcfuzzi develop 1 tail feather when they are born, and can grow additionaltall teathers during matunty depending on the alleles they inherit at a number of additive loci (T, S, and G) which form the geise/-complex. Each positive (+) allele adds one lalfeather and each negative - allele produces no additional feathers, based…
See the attachment and answer the following parts of the question: A) If the binturong genome is 2.87 x 109 base pairs, and the "highly repetitive DNA" fraction is composed entirely of copies of sequence 5'ATGGTCC3' and its complement, how many copies of this sequence are present in the binturong genome? B) Briefly explain, in your own words, why the fraction of the binturong DNA fragments that reannealed relatively slowly took so much longer to renature than the other DNA fragments. C) If you took more of the same randomly generated 1000 bp fragments of binturong DNA (the same sample that you used in the equilibrium density gradient centrifugation experiment described in part a and the C0t curve described in part b of this question) and used them as a sample in agarose gel electrophoresis, how many bands would you expect to find in the gel when you turned off the current and stained the gel with ethidium bromide? Briefly explain why you would predict that number of bands.
Of the genes in the microarray shown in the lower part of Figure 20.10, are most overexpressed or underexpressed in tumors from patients that remained cancer free for at least five years? Explain your reasoning.
Below are data from Jimenez et al (2022) depicting cellular expression patterns of the tumor suppressor transcription factor p53 (a gene commonly mutated in cancers). They explored oscillating expression patterns found in a mutated human cell line. Panel D shows measurements of changes in p53 mRNA levels measured using two different approaches; figure E shows measurements of protein levels from the same samples. The numbers on either side indicate the observed fold change (FC) in relative abundance of these molecules (note that any difference in values obtained between the two methods are not relevant for this question). Answer part b as pictured in the question
Topic: Recombinant pharmaceuticals (for the production of insulin, human growth hormone or blood clotting factors) Question Describe the molecular genetics process using proper scientific terminology. Describe the steps that are involved. How is it performed?
A. In what year was the National Bioethics Advisory Council formed? B. The first mammal clone to be produced from an adult (somatic cell)?