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A: Answer
Explain how hematopoietic stem cells were experimentally shown to be both multipotent and capable of self-renewal.
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- Discuss the principles that govern the presence and maintenance of stem cells both in vivo and in vitro? What is the current status of the technology, and its possible applications? What are the pros and cons of the technology, and how do these issues personally affect people?Describe the ATM-p53 repair pathway in normal cells and cancerous cellsGiven that the transgene used is only upregulated in the brain and spinal cord of TMFN mice, what might account for the TMFN mice having less severe cardiac dysfunction in response to LPS challenge?
- Describe the mutational event that produces the MYC oncogene in Burkitt’s lymphoma. Why does the particular mechanism for generating oncogenic MYC result in a lymphoma rather than another type of cancer? Describe another mechanism for generating oncogenic MYC.Is a hematopoietic cell pluripotent? Why or why not?why EGFR play a role in CRC and other cancer?