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- Hydroxyurea has been shown to increase the expression of fetal hemoglobin in adult red blood cells, by a mechanism that remains unclear. Explain why hydroxyurea can be a useful therapy for patients with sickle-cell anemia.Fluorouracil is a structural analogue of thymine. The fluorine promotes enolization. How is this effect used in thetreatment of cancer?Explain how NH4+ can be toxic to cells. How is this toxicity avoided?
