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A: Ames test is a biological assay to estimate the ability of a chemical compound to cause mutation.…
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A: Chemotherapy is a medication treatment that employs the use of potent chemicals to kill rapidly…
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A: An electrophoretic mobility shift assay (EMSA) is a common affinity electrophoresis technique used…
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A: In recombinant technology, vectors are the DNA molecules that are used as a vehicle which carry…
Q: how Gene Targeting Provides a Way toMutagenize Specific Genes?
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Q: Would the function of KRAS gene be lost or gained in MDA-MB-231 breast cancer derived cells? Please…
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Q: Are double-knockout animals (DKOs) and even triple-knockoutanimals (TKOs) also possible ?
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Q: Describe the rationale behind the electrophoretic mobility shift assay.
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Q: Discuss briefly the effects of colchicine treatment on cells. What are the genetic implications of…
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Q: How could site-directed mutagenesis be used to investigate the kinetic properties of an enzyme?
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Q: Explain why mRNA is preferred for making COVID-19 vaccines?
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Q: why is LDHA an attractive target for a cancer therapeutic?
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Q: Induced pluripotent stem cells have allowed scientists to model various diseases and screen drugs in…
A: Induced pluripotent stem cells (iPS cell) are immature cells that are created from a mature somatic…
Q: Describe briefly how MALDI and two-dimensional poly acrylamide gel electrophoresis could be used to…
A: The term proteomics is associated with biology field involving the study of proteins. This branch of…
Q: Why is NHEJ an error-prone mechanism?
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How might genomic information be helpful for the effective use of imatinib mesylate (Gleevec) in cancer chemotherapy?
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- Briefly describe the effects of colchicine treatment on cells. What are the genetic implications of such effects?Describe error prone polymerases and the process of translesion synthesis (TLS). In regards to tumor biology, what is the mutator phenotype hypothesis? What are some ways in which error-prone polymerases could be targeted for potential anti-cancer treatments?Why is DNA microarray an important tool and explain How is DNA microarray used in detecting cancer?
- Describe how mutations in genome maintenance factors promote tumorigenesis. Why would inactivation of a mis- match repair gene cause colon cancer?Why is it important to model cancer through the generation of induced pluripotent stem cells ? Please explain in detailsWhat percentage of cells in an organ or a tissue need toexpress a therapeutic gene to alleviate the effects of agenetic disorder?
- Why is NHEJ an error-prone mechanism?What is the definition of Driver Mutations & Passenger Mutations? Also describe why each are informative in characterizing tumors.In selecting target cells to receive a transferred gene in gene therapy, what factors do you think would have to be taken into account?
- Why Nutlin may represent a potential anti-cancer drug?Our understanding of the molecular biology of cancer formation has been greatly enhanced by studying oncogenic viruses. Answer the following questions regarding oncogenic retroviruses? Explain how a gain of function mutation in the Ras protein caused by a retrovirus might lead to cancer formation.Why is it important to model cancer through the generation of induced pluripotent stem cells ? Explain in detail the main findings. Please sort as a list.