Explain why people with a deficiency of the enzyme glucose 6-phosphate dehydrogenase (G6PDH) suffer from hemolytic anemia
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Explain why people with a deficiency of the enzyme glucose 6-phosphate dehydrogenase (G6PDH) suffer from hemolytic anemia
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- Explain how excessive ketone bodies may form in the following: During starvation In patients with diabetes mellitusDiscuss Hemolytic Anemia in linewith pentose phosphate pathway please include your referencesWhy people with PK deficiency may tolerate a lower hemoglobin level than people with other types of anemia in which 2,3-DPG is not elevated? explain as simple as possible
- Explain why the hexose monophosphate shunt is so important.Unlike primates and birds, many animals possess the enzyme urate oxidase. Suggest a reason why these organisms do not suffer from gout.Many patients with glucose 6- phosphatase deficiency have high serum levels of urate. Hyperuricemia can be induced in normal people by the ingestion of alcohol or by strenuous exercise. Propose a common mechanism that accounts for these findings.
- Why Succinate dehydrogenase (SDH) called deficiency? What are the probable causes? Explain.Diagram the Embden-Meyerhof anaerobic glycolytic pathway (EMP) in the red blood cell (RBC), highlighting adenosine triphosphate (ATP) consumption and generation.Propionic acidemia has a relatively high prevalence in South Africa, among both black and white families. This fatal disease is often diagnosed by the elevated presence of propionyl carnitine, propionylglycine and methyl citrate in blood and urine. Discuss the metabolism involved and origin of these markers.