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- Analysis of X-Linked Dominant and Recessive Traits As a genetic counselor investigating a genetic disorder in a family, you are able to collect a four-generation pedigree that details the inheritance of the disorder in question. Analyze the information in the pedigree to determine whether the trait is inherited as: a. autosomal dominant b. autosomal recessive c. X-linked dominant d. X-linked recessive e. Y-linkedAnalysis of X-Linked Dominant and Recessive Traits Suppose a couple, both phenotypically normal, have two children: one unaffected daughter and one son affected with a genetic disorder. The phenotype ratio is 1:1, making it difficult to determine whether the trait is autosomal or X-linked. With your knowledge of genetics, what are the genotypes of the parents and children in the autosomal case? In the X-linked case?Analysis of Autosomal Recessive and Dominant Traits Describe the phenotype and primary gene or protein defect of the X-linked recessive disease muscular dystrophy.
- Analysis of Autosomal Recessive and Dominant Traits Huntington disease is a rare, fatal disease that usually develops in the fourth or fifth decade of life. It is caused by a single autosomal dominant allele. A phenotypically normal man in his twenties who has a 2-year-old son of his own learns that his father has developed Huntington disease. What is the probability that he himself will develop the disease? What is the chance that his young son will eventually develop the disease?Analysis of X-Linked Dominant and Recessive Traits A young boy is color-blind. His one brother and five sisters are not. The boy has three maternal uncles and four maternal aunts. None of his uncles children or grandchildren is color-blind. One of the maternal aunts married a color-blind man, and half of her children, both male and female, are color-blind. The other aunts married men who have normal color vision. All their daughters have normal vision, but half of their sons are color-blind. a. Which of the boys four grandparents transmitted the gene for color blindness? b. Are any of the boys aunts or uncles color-blind? c. Is either of the boys parents color-blind?Analysis of Autosomal Recessive and Dominant Traits The father of 12 children begins to show symptoms of Huntington disease. a. What is the probability that Sam, the mans second-oldest son (II-2), will suffer from the disease if he lives a normal life span? (Sams mother and her ancestors do not have the disease.) b. Can you infer anything about the presence of the disease in Sams paternal grandparents?
- Analysis of Autosomal Recessive and Dominant Traits a. What pattern of inheritance is suggested by the following pedigree? b. For genotype assignment, assume that the pedigree is for an autosomal dominant trait and that the affected male in the first generation is heterozygous. Assign genotypes to all other individuals in the pedigree.Crossing Pea Plants: Mendels Study of Single Traits Sickle cell anemia (SCA) is a human genetic disorder caused by a recessive allele. A couple plan to marry and want to know the probability that they will have an affected child. With your knowledge of Mendelian inheritance, what can you tell them if (1) each has one affected parent and a parent with no family history of SCA or (2) the man is affected by the disorder but the woman has no family history of SCA?Bryan has albinism, an autosomal recessive trait, which means he is homozygous recessive for albinism and his genotype is aa. Bryan's parents, Frank and Amy, do not have albinism however they must both be heterozygous. Bryan's sister, Allice, is a carrier for albinism. If Allice has offspring with Jim, who has no family history of albinism, what are the chances that their offspring are carriers for albinism? What are the chances that they children will get albinism? Use Punnett squares.
- A boy has dimples (dominant trait of autosomal gene D) and is left-handed (recessive trait of autosomal gene H ). Which of these could NOT be the genotype of his MOTHER? dd HH DD hh Dd Hh DD HhA woman with Huntington’s disease (autosomal dominant trait, and she is heterozygous) has children with a healthy man. What proportion of their children will inherit Huntington’s disease?A couple is both heterozygous for the autosomal recessive disease cystic fibrosis (CF). What is the probability that their first child will either be a girl or have CF but not both?