Fill in the blanks to describe the sequence of molecular events that follow the binding of oxygen molecule to the first binding site in deoxy hemoglobin and lead to a T to R conformational change. Oxygen binds to one of the Hb subunits causing the to move about 0.4Á, causing that interacts with it via a coordination bond to move as well. This in turn causes an which is part of the same alpha helical segment _to move away from a nearby positively charged residue. As a result, this residue and an ion as broken, inducing the movement of C-terminus of the Hb subunit to which oxygen form and causes 2,3 pair that stabilises (intra or inter ?) subunit contacts bound toward the (center / edge?) of the Hb tetramer. This alters the overall fold of Hb monomers from to BPG to Give you answers is a numbered list starting from 1
Fill in the blanks to describe the sequence of molecular events that follow the binding of oxygen molecule to the first binding site in deoxy hemoglobin and lead to a T to R conformational change. Oxygen binds to one of the Hb subunits causing the to move about 0.4Á, causing that interacts with it via a coordination bond to move as well. This in turn causes an which is part of the same alpha helical segment _to move away from a nearby positively charged residue. As a result, this residue and an ion as broken, inducing the movement of C-terminus of the Hb subunit to which oxygen form and causes 2,3 pair that stabilises (intra or inter ?) subunit contacts bound toward the (center / edge?) of the Hb tetramer. This alters the overall fold of Hb monomers from to BPG to Give you answers is a numbered list starting from 1
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
Related questions
Question
![Fill in the blanks to describe the sequence of molecular events that follow the binding of oxygen molecule to the first binding site in deoxy
hemoglobin and lead to a T to R conformational change.
Oxygen binds to one of the Hb subunits causing the
to move about 0.4Å, causing
that interacts with it via a
coordination bond to move as well. This in turn causes an
which is part of the same alpha helical segment
as
to move away from a nearby positively charged
_residue. As a result, this residue
and an ion
pair that stabilises (intra or inter ?) subunit contacts is broken, inducing the movement of C-terminus of the Hb subunit to which oxygen
form and causes 2,3
to
bound toward the (center / edge?) of the Hb tetramer. This alters the overall fold of Hb monomers from
BPG to
Give you answers is a numbered list starting from 1](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fbe40947a-6845-4f98-8183-1cfb329e7e4d%2F87f94874-80ee-4b21-bdc2-faff7213b29e%2Fydh8glh_processed.jpeg&w=3840&q=75)
Transcribed Image Text:Fill in the blanks to describe the sequence of molecular events that follow the binding of oxygen molecule to the first binding site in deoxy
hemoglobin and lead to a T to R conformational change.
Oxygen binds to one of the Hb subunits causing the
to move about 0.4Å, causing
that interacts with it via a
coordination bond to move as well. This in turn causes an
which is part of the same alpha helical segment
as
to move away from a nearby positively charged
_residue. As a result, this residue
and an ion
pair that stabilises (intra or inter ?) subunit contacts is broken, inducing the movement of C-terminus of the Hb subunit to which oxygen
form and causes 2,3
to
bound toward the (center / edge?) of the Hb tetramer. This alters the overall fold of Hb monomers from
BPG to
Give you answers is a numbered list starting from 1
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