Furosemide (MM: 330.7 g/mol) is a diuretic derived from anthranilic acid, this diuretic is used in the treatment of kidney disease, hypertension, liver cirrhosis, and others. Furosemide in alkaline dissolution has an absorption spectrum with a maximum peak centered at 271 nm. The analysis of a furosemide tablet was performed by dissolving its content in a 0.1 mol L-1 NaOH solution and this dissolution completed for a volume of 100 mL, with 1.0 mL of this dissolution was transferred to 50.0 ml and made up to volume with the same solvent. It is dissolution has an absorbance value of 0.475 to 271 nm, with a 1.0 cuvette cm of optical path. At this wavelength, a series of dissolutions of a Standard substance of this drug has the following absorbance measurements (1.0 cm bucket): a) Demonstrate whether the experimental data are in accordance with Bee's law (b) Determine absorptivity and molar absorptivity (c) Determine the amount of drug in the tablet in mg and in ppm (d) Determine the concentration of a solution that absorbs 65%
Furosemide (MM: 330.7 g/mol) is a diuretic derived from anthranilic acid, this diuretic is used in the treatment of kidney disease, hypertension, liver cirrhosis, and others. Furosemide in alkaline dissolution has an absorption spectrum with a maximum peak centered at 271 nm. The analysis of a furosemide tablet was performed by dissolving its content in a 0.1 mol L-1 NaOH solution and this dissolution completed for a volume of 100 mL, with 1.0 mL of this dissolution was transferred to 50.0 ml and made up to volume with the same solvent. It is dissolution has an absorbance value of 0.475 to 271 nm, with a 1.0 cuvette cm of optical path. At this wavelength, a series of dissolutions of a Standard substance of this drug has the following absorbance measurements (1.0 cm bucket):
a) Demonstrate whether the experimental data are in accordance with Bee's law
(b) Determine absorptivity and molar absorptivity
(c) Determine the amount of drug in the tablet in mg and in ppm
(d) Determine the concentration of a solution that absorbs 65%
![10 C [molL-]
1
5
A (2 = 271 nm)
00,985
0,197
0,395
0,590
0,790](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F95ea9770-f522-4bfc-aa50-623967afb2d6%2F7f675bc7-b4e3-455d-9585-caabf9f116d0%2F9jknfzi_processed.jpeg&w=3840&q=75)
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